• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home StudyGraphics

#VisualAbstract: Arterial hyperoxia associated with mortality in critically ill children admitted to the pediatric intensive care unit

byMinjee Kim
January 13, 2022
in StudyGraphics
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

1. This large systematic review and meta-analysis of 16 studies and 27 555 patients found that, among critically ill children admitted to the pediatric intensive care unit, administration of supplemental oxygen causing hyperoxia was associated with increased mortality.

2. Future research is required to examine the implications of this formative association and its complex translation into critical care guidelines and practice.

Evidence Rating Level: 1 (Excellent)

Study Rundown: The administration of supplemental oxygen is one of the mainstay therapies in pediatric critical care. However, there is increasing evidence to show that over-administration of oxygen in critical situations leading to hyperoxia may be associated with detrimental outcomes compared to targeted normoxia. This study evaluated the association between hyperoxia and outcomes in critically ill children admitted to the pediatric intensive care unit (PICU) with the hypothesis that hyperoxia was associated with worse outcomes. The primary outcome was 28-day mortality and secondary outcomes included length of stay, ventilator-related outcomes, extracorporeal organ support, and functional performance. After completing a systematic review of 16 studies and meta-analysis of 11 studies comprising 23,204 total patients, hyperoxia was associated with an elevated odds ratio for mortality in this patient population. These findings suggested that oxygen above a certain dose may be harmful in critically ill children and should be supplied with caution. A limitation of this study was the substantial heterogeneity in the definition of hyperoxia used by the various studies as well as the observational and retrospective design of most selected studies, owing to a degree of subjectivity and interpretation of data that may affect statistical precision.

Click to read the study in JAMA Network Open

Relevant Reading: Arterial hyperoxia and mortality in critically ill patients: a systematic review and meta-analysis

RELATED REPORTS

Critical-care pain observation tool demonstrates reliability for critically ill pediatric patients

Epinephrine inferior to norepinephrine as initial treatment in children with septic shock

Characterization of meconium-related obstruction and outcomes in term and preterm infants

In-Depth [systematic review and meta-analysis]: This systematic search of EMBASE, MEDLINE, Cochrane Library, and ClinicalTrials.gov included 16 studies (27,555 patients) on outcomes of children admitted to the PICU with hyperoxia from inception to February 2021. The Meta-analysis of Observational Studies in Epidemiology guideline and Newcastle-Ottawa Scale for study quality assessment was used, where 2 independent reviewers completed the review process. All studies, except 1 randomized trial, were observational cohort studies, where data was pooled together via random-effects modeling. Studies included patient populations of various etiologies including post-cardiac arrest, traumatic brain injury, extracorporeal membrane oxygenation, and general critical care, where partial pressure of arterial oxygen was most frequently used to define hyperoxia. Among 11 studies (23,204 patients) included in the meta-analysis, hyperoxia was associated with an odds ratio of 1.59 (95%CI, 1.00-2.51; after Hartung Knapp adjustment, 95%CI, 1.05-2.38) for mortality with substantial between-study heterogeneity (I2 = 92%) and among less heterogeneous subsets. When data was pooled by definition of hyperoxia, a signal of harm was observed at higher thresholds of arterial oxygen levels.

©2022 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: critically ill childrenhyperoxianormoxiaoxygenoxygenationpediatric ICUPICUsupplemental oxygen
Previous Post

Wellness Check: Mental Health

Next Post

#VisualAbstract: Moderate-dose hydroxyurea does not decrease stroke incidence but may lower hospitalization rates in children with sickle cell anaemia, compared to low-dose hydroxyurea

RelatedReports

Neonatal neuroimaging with strong negative predictive value for developmental outcomes: The NEURO study
Emergency

Critical-care pain observation tool demonstrates reliability for critically ill pediatric patients

April 26, 2025
Pediatric palliative care outcome measures often miss quality of life
Emergency

Epinephrine inferior to norepinephrine as initial treatment in children with septic shock

April 20, 2025
Poverty, preterm birth demonstrate additive effect on cognition
Career Development

Characterization of meconium-related obstruction and outcomes in term and preterm infants

February 21, 2025
#VisualAbstract: No Difference in Risk Seen in Long-Term Oxygen Therapy for 24 vs 15 Hours per Day in Severe Hypoxemia
StudyGraphics

#VisualAbstract: No Difference in Risk Seen in Long-Term Oxygen Therapy for 24 vs 15 Hours per Day in Severe Hypoxemia

September 23, 2024
Next Post
#VisualAbstract: Moderate-dose hydroxyurea does not decrease stroke incidence but may lower hospitalization rates in children with sickle cell anaemia, compared to low-dose hydroxyurea

#VisualAbstract: Moderate-dose hydroxyurea does not decrease stroke incidence but may lower hospitalization rates in children with sickle cell anaemia, compared to low-dose hydroxyurea

Decreased expression of nasal ACE2 may be correlated with lower prevalence of COVID-19 in children

Complete vaccination with the BBV152 inactivated vaccine associated with protection against SARS-CoV-2 reinfection in health care workers

Fruit consumption among US youth differs by age, race

Fruit intake may improve mood after Pavlovian progressive muscle relaxation conditioning

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Cerebral embolic protection does not decrease stroke incidence in TAVI patients
  • Nerandomilast slows FVC decline in progressive pulmonary fibrosis
  • 2 Minute Medicine: Pharma Roundup – Gastric Immunotherapy Gains, Prostate Pill Expansion, Five-Minute Myeloma Dosing, and Streamlined CAR-T Access [July 8th 2025]
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.