• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home StudyGraphics

#VisualAbstract: Assessment of Combined Nivolumab and Bevacizumab in Relapsed Ovarian Cancer

byConstance Wu
November 5, 2019
in StudyGraphics
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. Nivolumab and bevacizumab combination therapy appears to be efficacious in relapsed epithelial ovarian cancer, especially in patients with platinum-sensitive disease.

Evidence Rating Level: 2 (Good)

Although previous investigations have indicated that the immune system plays an important role in ovarian cancer control, results from trials thus far on single-agent immune checkpoint inhibition have demonstrated limited clinical activity. Thus, it has been hypothesized that immune checkpoint inhibition could be potentiated by the addition of an agent that targets a separate pathway, such as bevacizumab, a VEGF-A inhibitor. In this phase II, single-arm study, 38 women with relapsed epithelial ovarian cancer (defined as disease recurrence within 12 months of their last platinum-based therapy) received intravenous nivolumab and intravenous bevacizumab once every 2 weeks to assess objective response rate (ORR) as measured by Response Evaluation Criteria for Solid Tumors (RECIST) 1.1. Secondary end points included evaluation of the ORR by platinum sensitivity, assessment of progression-free survival (PFS), investigation of the association of tumor PD-L1 with response to therapy, and safety. At baseline, 18 patients had platinum-resistant and 20 had platinum-sensitive disease, and the mean (SD) age was 63.0 (9.1) years. Researchers found that 11 patients responded to bevacizumab and nivolumab (ORR 28.9%, 95% CI 15.4% to 45.9%), 8 of which were patients with platinum-sensitive disease (ORR 40.0%, 95% CI 19.1% to 64.0%), and 3 of which were patients with platinum-resistant disease (ORR 16.7%, 95% CI 3.6% to 41.4%). Median progression-free survival (PFS) was 9.4 months (95% CI 6.7 months to NA), with a median PFS of 12.1 months (95% CI 8.4 months to NA) in platinum-sensitive patients and 7.7 months (95% CI 4.7 months to NA) in platinum-resistant patients. There were 10 confirmed or unconfirmed responses in patients with a PD-L1 tumor percentage lower than 1 (ORR 45.5%) and 2 in patients with a PD-L1 tumor percentage of 1 or more (ORR 14.3%). Adverse events were common; 34 participants (89.5%) experienced at least one treatment-related adverse event, and 9 participants (23.7%) experienced a grade 3 or higher treatment-related adverse event. This study was limited by the lack of a comparator arm and the small sample size. In summary, this study suggests that the combination of nivolumab and bevacizumab is efficacious in relapsed epithelial ovarian cancer, with greater activity in the platinum-sensitive setting. The results also reinforce the notion that PD-L1 expression may not be a reliable biomarker of response to immunotherapy in this disease.

Click to read the study in JAMA

©2019 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

RELATED REPORTS

Nivolumab plus ipilimumab improves survival over lenvatinib or sorafenib in liver cancer

Nivolumab plus ipilimumab improves progression-free survival in metastatic colorectal cancer

Durvalumab and bevacizumab plus chemoembolization improves progression-free survival in hepatocellular carcinoma

Tags: bevacizumabNivolumabovarian cancer
Previous Post

Ticagrelor alone non-inferior after one month post drug eluting stent placement

Next Post

Metoprolol not effective in preventing exacerbations of chronic obstructive pulmonary disease

RelatedReports

Prognostic indicators for transarterial chemoembolization in patients with hepatocellular carcinoma with extrahepatic spread identified
AI Roundup

Nivolumab plus ipilimumab improves survival over lenvatinib or sorafenib in liver cancer

June 12, 2025
Development of a risk index for colorectal cancer screening
Chronic Disease

Nivolumab plus ipilimumab improves progression-free survival in metastatic colorectal cancer

April 3, 2025
Prognostic indicators for transarterial chemoembolization in patients with hepatocellular carcinoma with extrahepatic spread identified
Chronic Disease

Durvalumab and bevacizumab plus chemoembolization improves progression-free survival in hepatocellular carcinoma

March 13, 2025
Increased risk of subsequent melanoma after first melanoma diagnosis
Dermatology

Neoadjuvant ipilimumab plus nivolumab improves event-free survival in stage III melanoma

December 12, 2024
Next Post
2 Minute Medicine Rewind May 20, 2019

Metoprolol not effective in preventing exacerbations of chronic obstructive pulmonary disease

#VisualAbstract: Polypill for Cardiovascular Disease Prevention in an Underserved Population

#VisualAbstract: Polypill for Cardiovascular Disease Prevention in an Underserved Population

Lung cancer screening may lower motivation for smoking cessation

Lung cancer screening according to existing guidelines is likely cost-effective

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Sodium-glucose cotransporter 2 inhibitors may decrease risk of serious liver events in patients with cirrhosis
  • #VisualAbstract: Lactated Ringer’s Solution Does Not Improve Outcomes Relative to Normal Saline
  • 2MM: AI Roundup – FDA’s AI Push, Trial Speedups with Real-World Data, Smart Surgical Monitors, and Regulatory Overhaul Begins [July 2nd, 2025]
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.