#VisualAbstract: N95 Respirators vs Medical Masks for Preventing Influenza Among Health Care Personnel

1. In this randomized controlled trial among outpatient health care personnel, N95 respirators were similar to medical masks for preventing laboratory-confirmed influenza.

2. N95 respirators and medical masks resulted in similar incidences of acute respiratory illness, laboratory-detected respiratory infections, laboratory-confirmed respiratory illnesses, and influenza-like illnesses.

Evidence Rating Level: 1 (Excellent)

Study Rundown: Health care personnel (HCP) are routinely exposed to viral respiratory infections in the workplace. Some experts argue that N95 respirators and medical masks are equivalent in clinical settings, though this has yet to be demonstrated. In this randomized clinical trial of outpatient providers, there was no significant difference in the incidence of laboratory-confirmed influenza among HCP between N95 respirators and medical masks. Further, N95 respirator and medical mask groups had similar incidences of acute respiratory illness, laboratory-detected respiratory infections, laboratory-confirmed respiratory illness, and influenza-like illness.

Despite this study’s suggestion that these two preventative device are equivocal for influenza prophylaxis, this study has some notable limitations. Participants were not instructed to wear protective devices outside the workplace, which may have biased the results toward finding no difference between groups. Only two N95 respirator and medical mask models were studied, limiting the ability to generalize about the protectiveness of other models. Lastly, the sample size required to definitively determine whether N95 respirators or medical masks are more effective for protection from laboratory-confirmed influenza in the health care setting required significantly more participant seasons than was feasible in this study setting.

Click to read the study in JAMA