Chronic Disease

Reports of high-impact chronic disease studies by medical professionals

Reduced yet persistent incidence of vertical HIV transmission in the United States

1. Overall incidence of vertical HIV transmission in the United States decreased from 2002 to 2013, and currently is at an estimated 1.75 per...

Effective subcutaneous C1-inhibitor for hereditary angioedema prophylaxis: The COMPACT trial

1. The self-administered, subcutaneous C1-inhibitor CSL830 demonstrated a dose-dependent high efficacy in the prophylactic treatment of hereditary angioedema (HAE) attacks compared to placebo. 2. CSL830...

Antioxidant supplementation did not decrease risk of dementia in older asymptomatic men: The PREADViSE...

1. Based on this double-blind randomized, controlled trial which evolved into a cohort study, asymptomatic men taking vitamin E, selenium or a combination of...

Canadians with cystic fibrosis have a significant survival advantage over American patients

1. After adjusting for risk factors associated with survival, Canadian patients had a median age of survival that was 10 years greater than in...

Anakinra not linked to reduction in fatigue severity in women with chronic fatigue syndrome

1. In a randomized, placebo-controlled trial of 50 women aged 18 to 59 years with chronic fatigue syndrome (CFS), the anti-inflammatory drug anakinra was...

Evolocumab demonstrated to have long-term efficacy at lowering low-density lipoprotiein: The Osler-1 trial

1. This multi-year, open-label extension of phase 2 trials examining the LDL-lowering efficacy of evolocumab (PCSK9-inhibitor) showed that evolocumab plus standard of care lipid...

Association between maternal body mass index in early pregnancy and incidence of cerebral palsy

1. This retrospective cohort study found that among Swedish women with singleton children, maternal overweight and obesity were significantly associated with incidence of cerebral...

Suboptimal dietary habits linked to deaths from heart disease, stroke, and type 2 diabetes

1. Over 45% of deaths due to heart disease, stroke, and type 2 diabetes in US adults in 2012 was due to suboptimal dietary...

Ischemic stroke from cervical artery dissection associated with history of migraine

1. In this case-control study of ischemic strokes in younger adults, stroke from cervical artery dissection (CEAD) was associated with increased prevalence of history...

Imatinib safe and effective as long-term treatment for chronic myeloid leukemia: The IRIS trial

1. The efficacy of imatinib in chronic phase chronic myeloid leukemia (CML) persisted after 10-year follow-up. 2. No new significant adverse events related to imatinib...
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