• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Cardiology

Acute caffeine ingestion does not increase arrhythmias in patients with chronic systolic heart failure

byShayna BejaimalandAnees Daud
October 20, 2016
in Cardiology
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

1. Based on a randomized, controlled trial, acute ingestion of caffeine was not pro-arrhythmogenic in chronic systolic heart failure patients during the physical stress of a treadmill test.

2. Increased plasma levels of caffeine also did not increase the risk of arrhythmias in these patients.

Evidence Rating Level: 1 (Excellent)

Study Rundown: It is controversial whether caffeine has proarrhythmic effects. Individuals with heart failure with reduced ejection fraction are at high risk for arrhythmias, and serve as an important population to understand this risk. This randomized controlled trial aimed to compare the effect of high-dose caffeine or placebo on the frequency of supraventricular and ventricular arrhythmias, both at rest and during a symptom-limited exercise test.

Acute ingestion of caffeine did not increase the risk of ventricular or supraventricular arrhythmias as compared to placebo in patients with chronic systolic heart failure, either at rest or during a symptom-limited exercise test. Strengths of the study included the randomized, controlled design of the study. Limitations of this study included its small sample size of 51 patients. While this study looked at the important question of caffeine’s risk on arrhythmia acutely, the risk after long-term, chronic ingestion is likely of greater clinical relevance.

Click to read the study, published today JAMA Internal Medicine

Relevant Reading: Randomized control trial investigating the influence of coffee on heart rate variability in patients with ST-segment elevation myocardial infarction

RELATED REPORTS

Interatrial shunt device not effective in patients with symptomatic heart failure

Moderate caffeine intake may not be associated with cardiometabolic pregnancy complications

Wellness Check: Nutrition

In-Depth [randomized controlled trial]: This double-blind, randomized controlled trial took place in at one tertiary-care university hospital in Brazil between March 2013 and October 2015. It utilized a crossover design. Patients included in the cohort had chronic heart failure with ejection fraction <45% and New York Heart Association functional classes I to III. Initially only patients with ICDs were included for safety purposes, but after finding no clinically significant events, the trial included patients without ICDs. Exclusion criteria was inability to ingest pills, major physical limitation to perform a treadmill stress test, use of anti-arrhythmic drugs except for beta-blockers and amiodarone, and recent hospitalization for heart failure <2 months to randomization. Following a 7-day washout, patients were randomized to either receive 500 mg of caffeine or lactose dissolved in decaffeinated coffee. Heart rate, ECG monitoring, and blood work occurred at baseline. After the initial phase, another 7-day wash out occurred and patient groups were switched. The primary outcome of interest was number and percentage of ventricular and supraventricular premature beats assessed by continuous electrocardiographic monitoring. This study used intention-to-treat statistical analysis.

Fifty-one patients were enrolled for randomization with a mean age of 60. These patients’ average left ventricular ejection fraction was 29%. There was no significant difference found between the caffeine and placebo groups with respect to ventricular (185 vs. 239 beats respectively; p = 0.47) or supraventricular premature beats (6 vs. 6 beats respectively; p = 0.44). During exercise, the same pattern remained, and exercise-related variables were also not influenced by acute caffeine ingestion. Finally, there was no increase in premature ventricular beats in patients with higher levels of plasma caffeine compared to lower levels (p = 0.91), or with placebo (p = 0.74).

Image: CC/Wiki

©2016 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: caffeinecongestive heart failuretachyarrhythmias
Previous Post

HBV and HCV coinfection may increase non-Hodgkin’s lymphoma risk in HIV-infected patients

Next Post

Early corticosteroid therapy associated with better outcomes in Kawasaki Disease

RelatedReports

30-Day mortality decreased in UK pediatric cardiac surgery from 2000-2010
Cardiology

Interatrial shunt device not effective in patients with symptomatic heart failure

March 29, 2022
Cognitive behavioral therapy effective for insomnia with medical or psychiatric comorbidities
Cardiology

Moderate caffeine intake may not be associated with cardiometabolic pregnancy complications

December 31, 2021
Provision of medically-tailored meals linked with lower admissions and medical spending
Wellness

Wellness Check: Nutrition

December 30, 2021
Caffeine affects teen boys, girls differently
Obstetrics

Low-to-Moderate caffeine intake during pregnancy is not associated with increased risk of maternal cardiometabolic complications

November 9, 2021
Next Post
Significant healthcare disparities exist between rural and non-rural children

Early corticosteroid therapy associated with better outcomes in Kawasaki Disease

ACP releases practice guidelines for the evaluation of suspected acute pulmonary embolism

Frequency of pulmonary embolism amongst patients admitted for first-time syncope

High rates of over-diagnosis of pulmonary embolism by CT angiography

2 Minute Medicine Rewind October 24, 2016

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Endoscopic sleeve gastroscopy effective for excess weight loss in type 1 and 2 obesity
  • #VisualAbstract: Early time-restricted eating was more effective for weight loss than eating over 12-hour window
  • Removal of asymptomatic kidney stones reduces risk of relapse
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.