• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Gastroenterology

Amoxicillin–clavulanate safer for patients with uncomplicated diverticulitis

byThomas SuandHarsh Shah
March 3, 2021
in Gastroenterology, Infectious Disease
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. The metronidazole-with-fluoroquinolone group had a significantly greater risk of Clostridioides difficile infection compared to the amoxicillin-clavulanate group.

2. The two treatment groups had similar rates of hospital admission risk, surgery risk, and overall burden of recurrent health care visits.

Evidence Rating Level: 2 (Good)

Study Rundown: Acute diverticulitis most commonly manifests without abscess or perforation; therefore, it can be managed on an outpatient basis. Currently, the two most popular regimens are amoxicillin-clavulanate or a combination of metronidazole and fluoroquinolone, but there has yet to be a direct comparison of efficacy and safety between the two alternatives. As such, this study assessed whether either treatment option resulted in any benefits or harms beyond the other. The treatment groups in both cohorts were similar with regard to 1-year diverticulitis-specific hospital admission risk, 1-year urgent surgery risk, 3-year elective surgery risk, and cumulative diverticulitis-related health care use. The 1-year infection risk was significantly greater among those who received metronidazole-with-fluoroquinolone compared to those who received amoxicillin-clavulanate. The study was limited by not investigating the safety outcomes, such as drug-induced liver injury. Overall, these findings suggest that treatment with amoxicillin-clavulanate may reduce the risk for fluoroquinolone-related harms without sacrificing efficacy.

Click here to read the study in Annals of Internal Medicine

Relevant Reading: Randomized clinical trial of observational versus antibiotic treatment for a first episode of CT‐proven uncomplicated acute diverticulitis

RELATED REPORTS

#VisualAbstract: Dequalinium chloride, a broad spectrum antiseptic, is non-inferior to metronidazole for bacterial vaginosis

#VisualAbstract: Addition of metronidazole is nonsuperior to conventional antibiotic prophylaxis in preventing pelvic cellulitis and pelvic abscess after total laparoscopic hysterectomy

Evaluating pediatric sinus antibiotics: effectiveness and safety comparison

In-Depth [retrospective cohort]: This active-comparator study utilized two separate cohorts, each drawing patient information from U.S. databases. Patients were eligible for inclusion if their first diagnostic code for outpatient diverticulitis occurred during 2000-2018 and the last prescription fill for the study antibiotics occurred at least six months before the new diagnosis. Patients were excluded if they were immunocompromised or had a prior diverticulitis-related diagnostic code, a percutaneous drain, or a colectomy for any indication. In one cohort, 106,361 (89.0%) patients filled prescriptions of metronidazole-with-fluoroquinolone and 13,160 (11.0%) filled prescriptions of amoxicillin-clavulanate. No between-group differences were observed in diverticulitis-specific 1-year hospital admission risk, 1-year urgent surgery risk, 3-year elective surgery risk, or 1-year risk for CDI. In the second cohort, 17,639 (86.7%) patients filled prescriptions of metronidazole-with-fluoroquinolone, and 2,709 (13.3%) filled prescriptions of amoxicillin-clavulanate. The two treatment groups had similar 1-year hospital admission risk and 3-year elective surgery risk, but the 1-year risk for CDI was significantly higher among those who received metronidazole-with-fluoroquinolone (1.2%) compared to those who received amoxicillin-clavulanate (0.6%) (95% confidence interval, 0.2 to 1.0 percentage points). Taken together, amoxicillin-clavulanate treatment reduced the risk of Clostridioides difficile infection compared to metronidazole-with-fluoroquinolone treatment.

Image: PD

©2021 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: amoxicillin–clavulanatediverticulitisfluoroquinolonemetronidazole
Previous Post

Interleukin-6 receptor antagonist treatment improves outcomes in COVID-19 patients

Next Post

#VisualAbstract: Aromatase inhibitors superior to tamoxifen for progression-free survival in HR⁺ advanced breast cancer

RelatedReports

#VisualAbstract: Dequalinium chloride, a broad spectrum antiseptic, is non-inferior to metronidazole for bacterial vaginosis
StudyGraphics

#VisualAbstract: Dequalinium chloride, a broad spectrum antiseptic, is non-inferior to metronidazole for bacterial vaginosis

June 1, 2024
#VisualAbstract: Addition of metronidazole is nonsuperior to conventional antibiotic prophylaxis in preventing pelvic cellulitis and pelvic abscess after total laparoscopic hysterectomy
StudyGraphics

#VisualAbstract: Addition of metronidazole is nonsuperior to conventional antibiotic prophylaxis in preventing pelvic cellulitis and pelvic abscess after total laparoscopic hysterectomy

April 19, 2024
Patient Basics: Acute Sinusitis
Infectious Disease

Evaluating pediatric sinus antibiotics: effectiveness and safety comparison

November 8, 2023
Patient Basics: Chronic Hepatitis
Chronic Disease

Amoxicillin-clavulanate not associated with improved survival outcomes in patients with severe alcohol-related hepatitis receiving prednisolone

May 29, 2023
Next Post
#VisualAbstract: Aromatase inhibitors superior to tamoxifen for  progression-free survival in HR⁺ advanced breast cancer

#VisualAbstract: Aromatase inhibitors superior to tamoxifen for progression-free survival in HR⁺ advanced breast cancer

Influenza vaccine not associated with increased risk of epilepsy in children

Heterologous recombinant adenovirus-based COVID-19 vaccine (Gam-COVID-Vac) is tolerable and highly efficacious

#VisualAbstract: Cemiplimab monotherapy significantly improves outcomes in patients with advanced non-small-cell lung cancer with PD-L1 of at least 50%

#VisualAbstract: Cemiplimab monotherapy significantly improves outcomes in patients with advanced non-small-cell lung cancer with PD-L1 of at least 50%

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Artificial intelligence based clinical decision systems are safe and effective for diabetes management
  • Epic Launchpad propels generative-AI into everyday hospital routines
  • #VisualAbstract: Routine Cerebral Embolic Protection Did Not Reduce Stroke Incidence during Transcatheter Aortic-Valve Implantation
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.