A novel therapy targeting γ-aminobutyric acid is safe and may be effective in major depressive disorder
1. H3-10353, a novel γ-aminobutyric acid (GABA) positive allosteric modulator, is safe and well-tolerated in healthy patients and those with...
A lower volume of polyethylene glycol with ascorbate (MoviPrep) may improve bowel cleansing prior to colonoscopy
1. 1 litre polyethylene glycol with ascorbate (1L-PEG-Asc) showed superior bowel cleansing efficacy compared to 2 litre polyethylene glycol with...
Immunosuppression with systemic glucocorticoids close to initiation of immune checkpoint inhibitor is associated with worse survival outcomes
1. Exposure to systemic glucocorticoid immunosuppression (gsISP) close to immune checkpoint inhibitor (ICI) initiation was associated with worse overall survival...
2 Minute Medicine Rewind May 25, 2026
Validation of 2 Syncope Risk Scores and Comparison With Physician Risk Estimation 1. The Canadian Syncope Risk Score (CSRS) and...
Treatment of chronic low back pain and disc herniation with amoxicillin-clavulanate (Augmentin) may not be effective for pain control
1. In adult patients with chronic low back pain (LBP) and disc herniation on magnetic resonance imaging (MRI), treatment with...
Delayed initiation of antibiotic therapy is associated with worse outcomes in skin and soft tissue infections
1. Delayed initiation of antibiotic therapy was strongly associated with treatment failure and prolonged hospitalization in hospitalized SSTI patients. 2....
Selective serotonin reuptake inhibitors may reduce risk of total joint arthroplasty in osteoarthritis
1. Initiation of centrally acting analgesics in patients with osteoarthritis (OA) was associated with a higher long-term risk of total...
Physical frailty is associated with increased risk of epilepsy
1. Physical frailty, particularly slow gait speed, was independently associated with a significantly increased risk of incident epilepsy in a...
A multimodal approach combining cognitive assessment with biomarkers may accurately predict dementia risk
1. Plasma p-tau217 was the strongest individual biomarker for predicting progression to Alzheimer's disease dementia in patients with subjective cognitive...
An intradialytic exercise intervention did not improve dialysis adequacy
1. A 4-week intradialytic pedalling exercise program was safe and well-tolerated but did not significantly improve dialysis adequacy measures. Evidence...
