Finerenone improves albuminuria in adults with type 1 diabetes and chronic kidney disease
1. In this phase 3 trial involving patients with type 1 diabetes and chronic kidney disease, finerenone was associated with...
![siRNA against antithrombin alleviates symptoms of hemophilia [PreClinical]](https://www.2minutemedicine.com/wp-content/uploads/2015/04/clot-CCWiki-350x250.jpg)
Apixaban reduces bleeding risk versus rivaroxaban in acute venous thromboembolism
1. In a randomized controlled trial of patients with acute venous thromboembolism, apixaban was associated with a substantially lower risk...
Smallpox therapy tecovirimat not efficacious in treating clade II mpox
1. In this phase 3, randomized, placebo-controlled trial, an antiviral medication approved for treating smallpox (tecovirimat) did not accelerate clinical...
Neoadjuvant therapy regimen improves outcomes in high-risk intrahepatic cholangiocarcinoma
1. In a randomized phase 2–3 trial of patients with resectable high-risk intrahepatic cholangiocarcinoma, neoadjuvant therapy with gemcitabine–oxaliplatin, lenvatinib, and...
Safety and efficacy profile of first-in-class oral p53 reactivator rezatapopt
1. In this phase 1-2 single-group trial, the p53 reactivator rezatapopt was well-tolerated in adults with solid tumors harboring the...
Ex vivo gene therapy for cystinosis had acceptable safety and improved disease biomarkers
1. In this phase 1–2 open-label study, autologous lentiviral hematopoietic stem-cell gene therapy for cystinosis was associated with sustained engraftment...
Safety and efficacy of novel antibody-oligonucleotide therapy for myotonic dystrophy type 1
1. In this phase 1-2 randomized controlled trial involving adults with myotonic dystrophy type 1, del-desiran was well-tolerated in most...
Oral nonstatin medication significantly lowers cholesterol in high-risk patients
1. In this randomized controlled trial, once-daily oral enlicitide was associated with sustained reductions in low-density lipoprotein cholesterol levels compared...
Chimeric antigen receptor T-cell therapy may induce sustained remission in multirefractory autoimmune hemolytic anemia
1. In this prospective cohort study, CD19-directed chimeric antigen receptor (CAR) T-cell therapy was found to elicit a complete response...
Tenecteplase not associated with visual improvement in central retinal artery occlusion
1. In this randomized controlled trial of adults with central retinal artery occlusion, tenecteplase administration shortly after symptom onset did...
