POT1-mediated long telomere syndrome is associated with familial clonal hematopoiesis
1. In this retrospective study, carriers with mutations in the gene encoding the protection of telomeres 1 protein (POT1) were...
Hematology
Characterization of cancer development risk following pediatric radiation exposure from computed tomography
Evidence rating level: 3 (Average) 1. Exposure to a higher cumulative number of pediatric CT scans is associated with a...
Quizartinib improves overall median survival in patients with acute myeloid leukemia
1. Overall survival in the quizartinib group was 31.9 months compared to 15.1 months in the placebo group. 2. Proportion...
Once-a-month fitusiran reduces bleeding rates in patients with hemophilia A and B with inhibitors
1. Annualized bleeding rate was reduced by 91% in the fitusiran prophylaxis group compared to the bypassing agents on-demand group....
Venetoclax in addition to ibrutinib effective as a treatment for chronic lymphocytic leukemia
1. High genetic risk participants with chronic lymphocytic leukemia (CLL) taking venetoclax in addition to ibrutinib achieved high rates of...
Dersimelagon reduces symptomatic disease in erythropoietic protoporphyrias
1. In this randomized controlled trial, oral dersimelagon resulted in significantly increased time to first symptoms among patients with erythropoietic...
Donor sex has no effect on survival in patients receiving red blood cell transfusions
1. In this randomized controlled trial, donor sex did not result in a significant difference in mortality amongst patients receiving...
Apixaban may be safer than other options for long-term anticoagulation
Comparative Effectiveness and Safety of Oral Anticoagulants by Dementia Status in Older Patients With Atrial Fibrillation 1. For older adults...
Incongruency between patients’ values and comfort-focused care on maintenance dialysis
1. Among patients undergoing maintenance dialysis, nearly half of patients valued comfort-focused care over life-prolonging care if they were to...
Sodium-glucose co-transporter-2 inhibitors may decrease risk of in-stent thrombosis
1. Sodium-glucose co-transporter-2 inhibitor (SGLT2i) use was associated with a decreased risk of in-stent restenosis (ISR) related major adverse cardiac...
