Trimethoprim-sulfamethoxazole during pregnancy does not reduce risk of prematurity
1. In this randomized controlled trial, prophylactic treatment with trimethoprim-sulfamethoxazole (TMP-SMX) was not associated with a reduction in the incidence...
Infectious Disease
Reports of high-impact infectious disease studies by medical professionals
Second-line TAF-based ART improves viral suppression in pediatric HIV
1. In this randomized controlled trial (CHAPAS-4), tenofovir alafenamide fumarate (TAF) with emtricitabine showed superior viral suppression at 96 weeks...
Oral gepotidacin is non-inferior to standard therapy for uncomplicated urogenital gonorrhea
1. Gepotidacin was non-inferior to ceftriaxone plus azithromycin for the primary outcome of microbiological success. 2. There were no serious...
Worsening kidney function observed following SARS-CoV-2 infection in children
1. In this cohort of children and adolescents, there was an association between SARS-CoV-2 infection and an increased risk of...
Twice-yearly lenacapavir prevents HIV more effectively than daily F/TDF
1. In this randomized controlled trial, among men and gender-diverse persons who have sex with men, it was found that...
Mepolizumab decreases exacerbations in patients with eosinophilic COPD
1. In this randomized controlled trial, mepolizumab decreased the annualized rate of moderate or severe exacerbations when added to triple...
Single-dose baloxavir linked to reduced influenza transmission
1. In this randomized controlled trial, influenza-positive patients who received a single dose of baloxavir had a 29% lower adjusted...
Poor baseline lung function associated with increased risk of incident tuberculosis
1. The risk of tuberculosis (TB) was higher in individuals with obstructive or restrictive lung function impairment compared to those...
Vaccinations may be associated with small but temporary changes in menstrual cycle length
1. Influenza vaccine given alone or concurrently with a COVID-19 vaccine was associated with a small (< 1 day) but...
Alcohol use disorder may be associated with human immunodeficiency virus
Alcohol Use Disorder Diagnoses Among Individuals Who Take HIV Preexposure Prophylaxis 1. In this cohort of individuals taking preexposure prophylaxis...
