Shorter antibiotic courses non-inferior for inpatient community-acquired pneumonia
1. In this target trial emulation, a shorter antibiotic course (3 to 4 days) demonstrated a similar 30-day all-cause mortality...
Infectious Disease
Reports of high-impact infectious disease studies by medical professionals
Next-generation yellow fever vaccine shows comparable efficacy to standard vaccine
1. A next-generation live-attenuated yellow fever vaccine (vYF) demonstrated noninferior immunogenicity compared to the standard vaccine, with nearly universal seroconversion...
Smallpox therapy tecovirimat not efficacious in treating clade II mpox
1. In this phase 3, randomized, placebo-controlled trial, an antiviral medication approved for treating smallpox (tecovirimat) did not accelerate clinical...
The quadrivalent human papillomavirus vaccine provides effective and durable protection against invasive cervical cancer
1. In this cohort study, the quadrivalent human papillomavirus (HPV) vaccine provides strong, long-lasting protection against invasive cervical cancer, with...
Metformin and ursodeoxycholic acid do not improve long COVID recovery
1. In this randomized controlled trial, neither metformin nor ursodeoxycholic acid improved recovery from long COVID compared with placebo in...
Poly-L-lysine-coated catheters are safe and well-tolerated in adults requiring short-term catheterization
1. Poly-L-lysine (PLL)-coated catheters are well-tolerated, safe, and noninferior in preventing bacteriuria compared to noble metal alloys (NMA)-coated catheters in...
Propofol is associated with lower mortality in sepsis-associated encephalopathy
1. Among patients with sepsis-associated encephalopathy, propofol monotherapy was associated with lower one-year all-cause mortality compared to no sedation therapy....
Mobile telemedicine is associated with higher chances of initiating hepatitis C virus treatment in intravenous drug users with chronic hepatitis C
1. Mobile telemedicine was associated with significantly higher chances of initiating hepatitis C virus (HCV) treatment and achieving viral clearance...
Fluoxetine may improve hemodynamic status and organ dysfunction in patients with severe sepsis
1. Adjunctive fluoxetine significantly reduced vasopressor duration and ICU length of stay in patients with severe sepsis. 2. Fluoxetine improved...
Pediatric patients with chronic medical conditions may have higher risk of invasive pneumococcal disease
1. Children and adolescents with chronic medical conditions have a significantly higher risk of invasive pneumococcal disease, particularly those who...
