Reinnervation of cardiac infarcts decreases subsequent arrhythmia incidence [PreClinical]

1. Genetically or pharmacologically blocking the tyrosine phosphatase receptor σ (PTPσ) in mice following myocardial infarction (MI) resulted in increased infarct reinnvervation and reduced...

Inhibiting cholesterol uptake decreases growth of pancreatic tumors [PreClinical]

1. Metabolic profiling of cells from mice bearing spontaneous pancreatic ductal adenocarcinoma (PDAC) revealed high upregulation of genes relating to cholesterol synthesis and storage...

Peptides mimicking cardiac receptors combat autoimmune-mediated heart failure [PreClinical]

1. In an animal model of autoimmune-mediated heart failure (HF), prophylactic or therapeutic treatment with a cyclopeptide mimicking a cardiac receptor dramatically blocked or...

Novel compound may correct pathological airway mucus in cystic fibrosis [PreClinical]

1. Mucus from cystic fibrosis patients had a rope-like structure and high elasticity due to chemical cross-links between mucin proteins. 2. A compound designed to...

Eliminating nighttime feeding decreases cardiac decline in fruit flies [PreClinical]

1. While flies subjected to time-restricted feeding (TRF) or ad libitum feeding (ALF) consumed similar total daily food quantities, TRF flies exhibited decreased age-related...

Novel drug inhibits MLL leukemia progression in mice [PreClinical]

1. Mice harboring tumors with translocations of the mixed lineage leukemia (MLL) gene showed decreased tumor size and increased survival times when treated with...

Small molecule drug may improve cancer-killing efficacy of oncolytic virus [PreClinical]

1. A small molecule screen identified that microtubule-destabilizing (MD) drugs enhanced the cancer-killing activity of oncolytic vesicular stomatitis virus. 2. In several mouse tumor...

Cutaneous microneedle flu vaccination reduces skin irritation and improves effectiveness [PreClinical]

1. Researchers developed a two-part method for cutaneous influenza vaccination: a microneedle array (MNs) that delivered vaccine without causing skin lesions, paired with a...

Birinapant shows efficacy in clearing hepatitis B infection [PreClinical]

1. The small molecule drug birinapant promoted elimination of hepatitis B virus (HBV) in a mouse model of chronic infection. 2. Combination therapy with...

Drug ameliorates effects of chronic kidney disease by targeting cell cytoskeleton [PreClinical]

1. Depletion of dynamin, a protein involved in maintenance of the actin cytoskeleton, resulted in decreased circulation of large proteins in zebrafish, which modeled...

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