Sparsentan superior to irbesartan for reduction of proteinuria in patients with IgA nephropathy
1. Patients in sparsentan group reported a 50% reduction in proteinuria compared to 15% in the irbesartan group at week...
Rheumatology
Ritlecitinib superior to placebo in the treatment of alopecia areata among teens and adults
1. Patients in the ritlecitinib group showed significant improvements in alopecia symptoms, with Severity of Alopecia Tool (SALT) scores ≤...
Price changes in colchicine have changed practice management for gout
1. The price increase of Colchicine in the United States led to greater use of alternative medications for gout treatment,...
Musculoskeletal disease likely a risk factor for development of dementias
1. Participants reporting a greater number of chronic pain sites had a higher proportion of developing incident all-cause dementia, AD,...
C-reactive protein may have superior prognostic value compared to low-density lipoprotein cholesterol for patients on statin therapy
1. High-sensitivity C-reactive protein increased the risk of all-cause mortality by two- to three-fold among all three randomized trials. 2....
Etrasimod improves clinical remission rates in patients with moderate-severe ulcerative colitis
1. In both ELEVATE UC 12 and ELEVATE UC 52, significantly greater patients in the etrasimod group achieved clinical remission...
Minimalist footwear reduces patellofemoral joint loads during running
1. In this systematic review and meta-analysis, it was found that minimalist footwear reduced the load experienced by the patellofemoral...
Secukinumab reduces symptoms of moderate-to-severe hidradenitis suppurativa
1. Patients receiving secukinumab every 2-weeks showed superior clinical response rates compared to those receiving placebo. 2. Secukinumab was well-tolerated,...
Sebetralstat improves symptom relief in acute hereditary angioedema attacks
1. An oral dose of sebetralstat increased the time to conventional treatment use and lead to faster symptom relief in...
Exercise may be as effective as pharmacotherapy in managing osteoarthritis pain
1. In this network meta-analysis, there was no difference between exercise, oral non-steroidal anti-inflammatory drugs (NSAIDs), and paracetamol with respect...
