KLKB1 gene editing therapy reduces kallikrein levels in hereditary angioedema
1. In this randomized controlled trial, gene-editing therapy targeting the kallikrein B1 gene (KLKB1) led to a significant reduction in...
Rheumatology
Methotrexate alleviates pain among patients with hand osteoarthritis and concurrent synovitis
1. Methotrexate 20 mg once weekly resulted in significant pain reduction among patients with hand osteoarthritis of the inflammatory phenotype....
Anxiety may be linked to C3 and C4 levels in patients with systemic lupus erythematosus
1. In this cross-sectional study, there was a significant negative correlation between anxiety scores and C3 levels in patients with...
Sarilumab increases remission rate in patients with polymyalgia rheumatica relapse
1. In this randomized controlled trial, patients with polymyalgia rheumatica (PMR) flares who received sarilumab with a prednisone taper demonstrated...
Spesolimab may improve quality of life in patients with generalized pustular psoriasis flares
1. Efficacy of spesolimab appeared to be dose-dependent with high-dose spesolimab leading to a significantly longer time to GPP flare-up...
Sodium-glucose cotransporter-2 inhibitors may decrease incidence of recurrent gout flares
1. Over a one-year period, the incidence of recurrent gout flares in patients with gout and diabetes was significantly lower...
Budesonide may be effective for slowing renal function decline in patients with IgA nephropathy
1. Reduction in time-weighted glomerular filtration rate (GFR) decline was significantly greater in Nefecon versus placebo. 2. Majority of adverse...
Cognitive behavioural therapy effective for fibromyalgia pain
1. This randomized controlled trial found that an 8-week cognitive behavioural therapy (CBT) intervention was more effective than fibromyalgia (FM)...
Combined digital intervention may be effective for osteoarthritis pain
1. Following total knee replacement (TKR) for osteoarthritis, patients randomized to a combined digital intervention experienced less pain, less disability,...
Baricitinib is safe and effective for treatment of refractory juvenile idiopathic arthritis
1. Time to disease flare was significantly shorter in the placebo group versus baricitinib. 2. There was no difference in...
