The CURB-65 score: Risk stratifying patients with community-acquired pneumonia [Classics Series]
1. Patients with community-acquired pneumonia (CAP) can be stratified into mortality risk groups using a five-point score. 2. One point...
Emergency Classics
Physician-written reports of landmark emergency medicine studies
The CORTICUS trial: Hydrocortisone in septic shock [Classics Series]
Image: PD 1. There was no significant difference in mortality between patients with septic shock receiving low-dose hydrocortisone compared to...
The SOAP-II trial: First-line vasopressor for shock management [Classics Series]
Image: PD 1. There were no significant differences in 28-day, 6-month, or 12-month mortality when comparing dopamine and norepinephrine as...
The HMPS I: Adverse events in patients and negligence [Classics Series]
Image: PD 1. It was found that adverse events occurred in 3.7% of hospitalizations. 2. Approximately 27.6% of adverse events occurring...
The Canadian CT Head Rule [Classics Series]
Image: CC/L. academia 1. The Canadian CT Head Rule consists of 7 predictor variables to assess the need for CT imaging...
The ECASS III trial: Administering recombinant t-PA up to 4.5 hours after onset of acute ischemic stroke improves neurological outcomes [Classics Series]
Image: CC/L. academia 1. Alteplase administered between 3 to 4.5 hours after the onset of acute ischemic stroke improves...
The NINDS trial: Tissue plasminogen activator in acute ischemic stroke significantly improves functional outcomes [Classics Series]
1. Treatment of acute ischemic stroke with tissue plasminogen activator within 3 hours of symptom onset significantly improves functional outcomes...
The Rivers trial: Early goal-directed therapy in severe sepsis and septic shock [Classics Series]
1. Early goal-directed therapy in patients with severe sepsis and septic shock prior to admission to the intensive care unit...
The HOPE trial: Ramipril significantly reduces cardiovascular events in high-risk patients with normal ejection fractions [Classics Series]
Image: CC/L. academia 1. Ramipril significantly reduces cardiovascular events including MI, stroke and death in high risk-patients in the absence...
The TRICC trial: Restrictive transfusion in intensive care does not increase mortality [Classics Series]
1. Using a restrictive transfusion strategy in critically ill patients did not significantly increase 30-day mortality when compared with a...