Emergency Classics

Physician-written reports of landmark emergency medicine studies

The DOSE trial: Loop diuretic strategies in acute decompensated heart failure [Classics Series]

1. The use of loop diuretics in acute decompensated heart failure is commonplace, but clinical practice varies widely with regards to the dosage and...

The EVS: Vitrectomy results in better visual outcomes for light-perception patients [Classics Series]

1. In patients with endophthalmitis after recent lens implantation, immediate vitrectomy significantly improved visual outcomes for patients presenting with light-perception visual acuity compared to...

The ONTT: Intravenous steroids lead to faster visual recovery in optic neuritis [Classics Series]

1. In patients with first presentation of optic neuritis, treatment with intravenous methylprednisolone followed by oral prednisone resulted in faster visual recovery when compared...

The FREEDOM trial: Coronary bypass graft vs. PCI in diabetic patients [Classics Series]

1. In patients with diabetes and multivessel disease, coronary artery bypass grafting (CABG) was shown to be superior to percutaneous coronary intervention (PCI) with...

The ICAP trial: Colchicine in acute pericarditis [Classics Series]

1. Colchicine has been commonly used in the treatment of inflammatory conditions, including gout and serositis.2. This study demonstrated that colchicine, in addition to...

The BHAT: Propranolol after acute myocardial infarction [Classics Series]

1. Beta-blockers were commonly used in the treatment of coronary artery disease in the 1980s, though prior studies were inconclusive due to limitations in...

The VALIANT trial: Valsartan vs. captopril in patients with acute myocardial infarction and heart...

1. In patients with acute myocardial infarction and heart failure/evidence of left ventricular dysfunction, patients treated with valsartan and captopril experienced similar all-cause mortality.2....

Ceftriaxone vs. norfloxacin for prophylaxis in patients with cirrhosis and gastrointestinal bleeding [Classics Series]

1. In cirrhotic patients who presented with gastrointestinal bleeding, patients treated with ceftriaxone were significantly less likely to develop proved or possible infections when...

Delayed antimicrobial therapy linked with higher mortality in septic shock [Classics Series]

1. Septic shock is a complication of infection with very high mortality rates.2. This study was one of the first to demonstrate that delaying...
Classics Series, Landmark Trials in Medicine

Prednisolone vs placebo in severe alcoholic hepatitis [Classics Series]

1. Compared to placebo, treating patients with severe alcoholic hepatitis with 28 days of prednisolone significantly improved the short-term survival up to 6 months.2....
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