Classics Series, Landmark Trials in Medicine

The HAPO trial: hyperglycemia and adverse pregnancy outcomes [Classics Series]

1. Impaired glucose tolerance on the 2-hour glucose tolerance test was associated with increased odds of primary cesarean delivery, large for gestational age (LGA)...
Classics Series, Landmark Trials in Medicine

Gestational diabetes treatment improves maternal outcomes [Classics Series]

1. Women randomized to treatment of mild gestational diabetes were less likely to experience shoulder dystocia, cesarean delivery, gestational hypertensive disease or deliver large...
Classics Series, Landmark Trials in Medicine

Letrozole superior to clomid for ovulation induction in PCOS [Classics Series]

1. Women with polycystic ovary syndrome (PCOS) randomized to receive letrozole had more live births than women randomized to clomiphene (27.5% vs. 19.1%, p=0.007). 2....
Classics Series, Landmark Trials in Medicine

The Women’s Health Initiative: Risks outweigh benefits of combination hormone replacement therapy [Classics Series]

1. Combination estrogen and progestin hormone replacement therapy (HRT) is associated with a 29% increased risk of cardiovascular disease, 110% increased risk of venous...
Classics Series, Landmark Trials in Medicine

Twin vaginal delivery as safe as cesarean [Classics Series]

1. Among women with cephalic-presenting diamniotic twins at term, those randomized to planned cesarean delivery were not more likely to experience adverse neonatal outcomes...
Classics Series, Landmark Trials in Medicine

Most ovarian cysts resolve, sonographic surveillance recommended [Classics Series]

1. The majority (>60%) of ovarian abnormalities, even complex, solid or bilateral cysts, resolved with serial ultrasounds. 2. Complex-appearing cysts resolved more quickly than simple-appearing...
Classics Series, Landmark Trials in Medicine

Nurses’ Health Study: Estrogen associated with lower cardiovascular disease risk [Classics Series]

1. Healthy postmenopausal nurses aged 30-53 years on estrogen therapy had a 44% reduced risk of major coronary disease compared to women not on...
Classics Series, Landmark Trials in Medicine

HPV triage is optimal management for ASCUS [Classics Series]

1. A single human papillomavirus (HPV) test identified 92.4% of women diagnosed with CIN-III. 2. A strategy of HPV triage testing detected high-grade intraepithelial lesion...
Classics Series, Landmark Trials in Medicine

Cerclage prevents recurrent preterm birth in women with short cervix [Classics Series]

1. In women with a history of prior preterm birth less and midtrimester cervical length <25mm, cerclage reduced perinatal morbidity and preterm delivery at...
Classics Series, Landmark Trials in Medicine

Magnesium reduces cerebral palsy in infants delivered early preterm [Classics Series]

1. Among women with imminent delivery between 24 and 31 weeks gestation, those randomized to receive magnesium sulfate experienced a decreased risk of moderate...
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