Cervical length indicates risk of preterm delivery [Classics Series]

1. Transvaginal cervical length measured at 24 and 28 weeks gestation was inversely associated with risk of spontaneous preterm delivery in a dose-dependent manner. Original...
Classics Series, Landmark Trials in Medicine

Anastrazole superior to tamoxifen for breast cancer treatment [Classics Series]

1. Postmenopausal women with advanced breast cancer randomized to anastrazole as first-line therapy experienced an increase in time to progression and a more favorable...

Antenatal steroids for fetal lung maturity [Classics Series]

1. Respiratory distress syndrome (RDS) and perinatal mortality were significantly less common among preterm infants whose mothers received betamethasone prior to delivery. Original Date...

Periconceptional folic acid for prevention of neural tube defects [Classics Series]

1. Among women seeking pregnancy, those randomized to folic acid supplementation were significantly less likely to develop a fetus with a neural tube defect. Original...

Cesarean delivery for term breech not associated with long-term benefit [Classics Series]

1. At 2 years of follow-up, planned cesarean delivery was not associated with reduction in neurodevelopmental delay compared to planned vaginal delivery for term breech...
Classics Series, Landmark Trials in Medicine

Glyburide as effective as insulin for gestational diabetes [Classics Series]

1. Among women with gestational diabetes requiring treatment, those randomized to glyburide achieved similar glycemic control to women in the insulin control group. Original Date...

Association of bacterial vaginosis and low birthweight infants [Classics Series]

1. Bacterial vaginosis (BV) is associated with 40% increased odds of preterm delivery of a low birthweight (LBW) infant. Original Date of Publication: December 1995 Study...

The Magpie trial: Magnesium lowers eclampsia risk [Classics Series]

1. Women with pre-eclampsia randomized to magnesium experienced a greater than 50% reduction in eclampsia compared to women on placebo. Original Date of Publication: June...

2 Minute Medicine Rewind November 9 – 15, 2015

  Effect of Clopidogrel and Aspirin vs. Aspirin Alone on Migraine Headaches After Transcatheter Atrial Septal Defect Closure: The CANOA Randomized Clinical Trial New-onset migraines affect...

High fertilization rates following intracytoplasmic sperm injection (ICSI) [Classics Series]

1. Among infertile couples with poor prognosis and/or severe male factor infertility, intracytoplasmic sperm injection (ICSI) was associated with higher fertilization, implantation, and pregnancy...
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