The ATLAS trial: Duration of adjuvant tamoxifen in ER-positive breast cancer [Classics Series]
Image: PD 1. Among women with early ER-positive breast cancer, continuing adjuvant tamoxifen for 10 years versus stopping at 5...
Surgery Classics
Physician-written reports of landmark surgery studies
The PANTER trial: Open necrosectomy vs step-up approach for necrotizing pancreatitis [Classics Series]
Image: PD 1. A minimally invasive step-up approach significantly reduced the rate of major complications as compared to open necrosectomy...
The PLCO trial 1: PSA and digital rectal examination in prostate cancer screening [Classics Series]
Image: PD 1. Subjects undergoing annual prostate-specific antigen (PSA) testing for 6 years and annual digital rectal examination (DRE) for...
Initial trial of conservative management of splenic injury [Pediatrics Classics Series]
Image: PD 1. The conservative, symptomatic management of 16 patients following assumed splenic injury from blunt abdominal trauma resulted in...
The PLCO trial 2: Flexible sigmoidoscopy in colon cancer screening [Classics Series]
Image: PD 1. Screening with flexible sigmoidoscopy is associated with a significant decrease in colon cancer incidence in the distal...
Endoscopic biliary drainage in acute cholangitis [Classics Series]
Image: PD 1. For patients with severe acute cholangitis due to choledocholithiasis, endoscopic biliary drainage reduces hospital mortality compared to...
The ARMA trial: Lower tidal volume ventilation in ALI/ARDS [Classics Series]
1. The trial was terminated early when the data demonstrated that lower tidal volume ventilator settings in ALI/ARDS patients led...
Early TIPS in cirrhosis and variceal bleeding [Classics Series]
Image: PD 1. In patients with severe liver disease and variceal bleeding, early transjugular intrahepatic portosystemic shunt (TIPS) significantly reduced...
The Symplicity HTN-2 trial: Renal denervation in treatment-resistant hypertension [Classics Series]
Image: PD 1. Renal denervation significantly reduces blood pressure in patients suffering from treatment-resistant hypertension 2. Renal denervation was not...
The NASCET: Carotid endarterectomy for symptomatic stenosis [Classics Series]
Image: PD 1. Carotid endarterectomy, in addition to medical therapy, significantly reduces risk of major and fatal stroke in patients...