The ARMA trial: Lower tidal volume ventilation in ALI/ARDS [Classics Series]
1. The trial was terminated early when the data demonstrated that lower tidal volume ventilator settings in ALI/ARDS patients led...
Surgery Classics
Physician-written reports of landmark surgery studies
Early TIPS in cirrhosis and variceal bleeding [Classics Series]
Image: PD 1. In patients with severe liver disease and variceal bleeding, early transjugular intrahepatic portosystemic shunt (TIPS) significantly reduced...
The Symplicity HTN-2 trial: Renal denervation in treatment-resistant hypertension [Classics Series]
Image: PD 1. Renal denervation significantly reduces blood pressure in patients suffering from treatment-resistant hypertension 2. Renal denervation was not...
The NASCET: Carotid endarterectomy for symptomatic stenosis [Classics Series]
Image: PD 1. Carotid endarterectomy, in addition to medical therapy, significantly reduces risk of major and fatal stroke in patients...
The HMPS II: Characterizing adverse events in hospitalized patients [Classics Series]
Image: PD 1. Drug-related complications were the most common type of adverse event in hospitalized patients. 2. Adverse events due to...
The PRECOMBAT trial: PCI vs CABG in left main coronary artery stenosis [Classics Series]
1. In patients with left main coronary artery stenosis, angioplasty with sirolimus-eluting stents was noninferior to coronary artery bypass grafting...
The EINSTEIN-DVT trial: Rivaroxaban in acute deep-vein thrombosis [Classics Series]
Image: PD 1. Rivaroxaban is non-inferior to standard therapy of enoxaparin and vitamin K antagonist in treating acute, symptomatic deep-vein...
The CREST trial: Stenting versus endarterectomy for carotid stenosis [Classics Series]
Image: PD 1. The rate of stroke, myocardial infarction or death did not differ significantly between patients treated with carotid...
The MELD score: Predicting survival in end-stage liver disease [Classics Series]
Image: PD 1. The Model for End-Stage Liver Disease (MELD) is a reliable tool for predicting short-term survival in patients...
The PIVOT trial: Radical prostatectomy versus observation [Classics Series]
Image: PD 1. Prostatectomy did not significantly reduce all-cause mortality or prostate-cancer mortality when compared to observation 2. These findings...