• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home The Classics Surgery Classics

The PIVOT trial: Radical prostatectomy versus observation [Classics Series]

byAndrew Cheung, MD MBA
July 11, 2013
in Surgery Classics, The Classics
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

Image: PD

1. Prostatectomy did not significantly reduce all-cause mortality or prostate-cancer mortality when compared to observation

2. These findings support conservative management for men with localized prostate cancer, especially for those with PSA values less than 10 ng/mL and low-risk disease

Original Date of Publication: July 19, 2012

Study Rundown: The incidence of prostate cancer in men is relatively high, but high long-term survival rates have been observed with conservative management. The treatment of localized prostate cancer is controversial as few trials have compared surgical intervention to observation in the time since prostate specific antigen (PSA) testing has become a common screening tool. This study found no significant difference in all-cause or prostate-cancer mortality following radical prostatectomy compared to observation. These findings suggest that observation is a safe strategy in managing localized prostate cancer and avoids the unnecessary risks of intervention. The results also show that PSA levels and tumour risk may be useful in identifying patients who will benefit from radical prostatectomy. Strengths of the study include the representative sample and measurement of all-cause mortality as the primary outcome which avoids biased assessments of cause-of-death. Of note, the study may have been underpowered as the investigators intended to enroll 2,000 participants, but reduced the sample size to 731. In addition, a substantial number of patients did not adhere to the assigned treatment in both groups, which could influence the observed treatment effect.

Please click to read study in NEJM

In-Depth [randomized, controlled study]: Published in NEJM in 2012, this randomized controlled trial assessed the effectiveness of surgery versus observation for men with localized prostate cancer. The trial included 731 men and followed participants for a median of 10 years. The primary outcome was all-cause mortality and a secondary outcome was prostate-cancer mortality, defined as death due to prostate cancer or prostate cancer treatment. The rate of all-cause mortality was not significantly different between the two groups with an absolute risk reduction of 2.9 percentage points in the radical-prostatectomy group. There was also no significant difference between groups in prostate cancer mortality. A significant interaction was found between study group and baseline PSA value. In men with a PSA value greater than 10 ng/mL, a significant reduction in all-cause mortality was observed with surgery, though surgery did not reduce all-cause mortality in men with a PSA less than or equal to 10 ng/mL.

RELATED REPORTS

Plant-based diets may be associated with lower risk of aggressive prostate cancer

#VisualAbstract: Tamoxifen increases the risk of endometrial cancer in premenopausal women with breast cancer

Early-life body size not an independent risk factor for colorectal cancer

By Adrienne Cheung, Andrew Cheung, M.D.

© 2013 2minutemedicine.com. All rights reserved. No works may be reproduced without written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No post should be construed as medical advice and is not intended as such by the authors or by 2minutemedicine.com. PLEASE SEE A HEALTHCARE PROVIDER IN YOUR AREA IF YOU SEEK MEDICAL ADVICE OF ANY SORT. Content is produced in accordance with fair use copyrights solely and strictly for the purpose of teaching, news and criticism. No benefit, monetary or otherwise, is realized by any participants or the owner of this domain.

Tags: canceroncologyPIVOTprostateprostatectomy
Previous Post

Alternative treatment for acute promyelocytic leukemia promising

Next Post

African Americans, obese overrepresented in young heart failure cases

RelatedReports

Vegetarian diet may lower incidence of colorectal cancer
Lifestyle

Plant-based diets may be associated with lower risk of aggressive prostate cancer

January 27, 2023
#VisualAbstract: Tamoxifen increases the risk of endometrial cancer in premenopausal women with breast cancer
StudyGraphics

#VisualAbstract: Tamoxifen increases the risk of endometrial cancer in premenopausal women with breast cancer

January 24, 2023
Benefits of high-intensity surveillance following colorectal adenoma removal likely outweigh costs
Chronic Disease

Early-life body size not an independent risk factor for colorectal cancer

January 11, 2023
No benefit of erlotinib in combined hepatocellular carcinoma treatment
Oncology

Spiritual care reduces fatigue and pain among patients receiving chemotherapy

January 11, 2023
Next Post
Gestational weight loss may improve outcomes for obese women

African Americans, obese overrepresented in young heart failure cases

Everolimus only protects against early cardiac allograft vasculopathy

Antibiotic implants reduce surgical site infections

Preterm delivery associated with long-term maternal cardiovascular risk

Preterm delivery associated with long-term maternal cardiovascular risk

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • BNT162b2 booster is safe and reduces COVID-19 transmission in older adults
  • Bisphosphonates, denosumab, abaloparatide, teriparatide, and romosozumab reduce postmenopausal fracture risk
  • Epstein-Barr viral load monitoring reduces risk of post-liver transplant lymphoproliferative disease
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options