Tag: cancer

Advance care planning in patients with advanced cancer: A 6-country, cluster-randomised clinical trial 1. An advanced care planning (ACP) intervention was not found to increase quality of life compared to usual care, in patients with advanced lung or colorectal cancer. 2. ACP was found to increase the number of patients receiving...

1. There was no significantly increased risk of ICU admission, intubation, or death among hospitalized patients with COVID-19 and active malignancy compared with a matched cohort of patients with COVID-19 and no malignancy. Evidence Level Rating: 2 (Good) Some institutions in the U.S. have reported higher rates of COIVD-related complications and...

1. Sarcopenia was an independent risk factor for reduced muscle mass and strength following liver resection for malignant neoplasms. Evidence Rating Level: 2 (Good) Sarcopenia is an involuntary, age-related loss of skeletal muscle mass and strength. This condition is known to drastically impact postoperative and oncological outcomes following liver resection for...

1. Adding bevacizumab to mFOLFOX6 therapy among patients with RAS mutant metastatic colorectal cancer led to an increased rate of liver metastases resection, which has previously been demonstrated to improve survival. 2. Bevacizumab addition to standard therapy was associated with increased overall survival and progression-free survival at three years. Evidence Rating...

1. Unexpected weight loss, in male ever smokers aged 50 and older, meets the 3% predictive value for warranting a cancer investigation. Evidence Rating Level: 2 (Good) Unexpected weight loss (UWL) is reported in 1.5% of adults seeing a primary healthcare provider. Past studies have found associations between UWL and early...

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study 1. In patients with confirmed SARS-CoV-2 infection within 7 days before or 30 days after surgery, significant mortality was observed, and perioperative pulmonary complications occurred in more than half the patients. Evidence Rating: 2 (Good) Current...

1. Adolescent obesity was significantly associated with cancer incidence in young and mid adulthood, and could be an important intervention target for early cancer prevention Evidence Rating: 2 (Good) Despite obesity being an established causal factor for at least 12 types of cancer, the relationship between youth obesity and cancers have...

Dexamethasone treatment for the acute respiratory distress syndrome: a multicentre, randomised controlled trial 1. Study findings suggest that early administration of intravenous dexamethasone during acute respiratory distress syndrome may decrease duration of mechanical ventilation and mortality rates. Evidence Level: 1 (Excellent) Acute respiratory distress syndrome (ARDS), characterized by acute hypoxemic respiratory failure...

1. Compared to standard photon therapy, proton chemoradiotherapy resulted in significantly reduced reduction in adverse events without changing disease-free or overall survival rates. Evidence Rating Level: 2 (Good) The standard of care for many cancers is concurrent chemoradiotherapy, which can be associated with significant morbidity. The administration of proton therapy as...

Association of Intrinsic Brain Architecture With Changes in Attentional and Mood Symptoms During Development 1. Resting-state functional connectivity between several brain regions may serve as a useful biomarker to predict future neuropsychiatric symptoms such as attention deficits, anxiety, and depression in children. Evidence Rating Level: 2 (Good) Neurodevelopment has become an important...