Tag: cancer

1. Adding bevacizumab to mFOLFOX6 therapy among patients with RAS mutant metastatic colorectal cancer led to an increased rate of liver metastases resection, which has previously been demonstrated to improve survival. 2. Bevacizumab addition to standard therapy was associated with increased overall survival and progression-free survival at three years. Evidence Rating...

1. Unexpected weight loss, in male ever smokers aged 50 and older, meets the 3% predictive value for warranting a cancer investigation. Evidence Rating Level: 2 (Good) Unexpected weight loss (UWL) is reported in 1.5% of adults seeing a primary healthcare provider. Past studies have found associations between UWL and early...

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study 1. In patients with confirmed SARS-CoV-2 infection within 7 days before or 30 days after surgery, significant mortality was observed, and perioperative pulmonary complications occurred in more than half the patients. Evidence Rating: 2 (Good) Current...

1. Adolescent obesity was significantly associated with cancer incidence in young and mid adulthood, and could be an important intervention target for early cancer prevention Evidence Rating: 2 (Good) Despite obesity being an established causal factor for at least 12 types of cancer, the relationship between youth obesity and cancers have...

Dexamethasone treatment for the acute respiratory distress syndrome: a multicentre, randomised controlled trial 1. Study findings suggest that early administration of intravenous dexamethasone during acute respiratory distress syndrome may decrease duration of mechanical ventilation and mortality rates. Evidence Level: 1 (Excellent) Acute respiratory distress syndrome (ARDS), characterized by acute hypoxemic respiratory failure...

1. Compared to standard photon therapy, proton chemoradiotherapy resulted in significantly reduced reduction in adverse events without changing disease-free or overall survival rates. Evidence Rating Level: 2 (Good) The standard of care for many cancers is concurrent chemoradiotherapy, which can be associated with significant morbidity. The administration of proton therapy as...

Association of Intrinsic Brain Architecture With Changes in Attentional and Mood Symptoms During Development 1. Resting-state functional connectivity between several brain regions may serve as a useful biomarker to predict future neuropsychiatric symptoms such as attention deficits, anxiety, and depression in children. Evidence Rating Level: 2 (Good) Neurodevelopment has become an important...

Pregnancy duration and endometrial cancer risk: nationwide cohort study Full-term pregnancies are strongly associated with a reduced risk of endometrial cancer. Whether this protective association is driven by fecundity, a specific process that occurs during pregnancy, or cumulative number of months pregnancy, however, is unknown. In this cohort study, 2,311,332...

Association between heart failure and postoperative mortality among patients undergoing ambulatory noncardiac surgery Patients with heart failure are at an increased risk of experiencing postoperative adverse events and mortality. While ambulatory surgical procedures are perceived as being low risk, morbidity and mortality outcomes in this surgical setting have not been...

It has been well established that the consumption of sugary drinks is linked to an increased risk of weight gain, diabetes, hypertension and cardiovascular disease. The association between sugary drink consumption and cancer, however, has been less investigated. NutriNet-Santé is a French, web-based cohort, that was established in 2009...