• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Pediatrics

CPAP found equal to intubation in extremely premature infants in the NICU

bys25qthea
April 17, 2013
in Pediatrics, Surgery
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

 

[tabs tab1=”2MM Rundown” tab2=”Full 2MM Report”]

[tab]

Image: PD

1. Continuous Positive Airway Pressure (CPAP) may be a viable alternative to early intubation with surfactant administration in extremely preterm infants in the NICU.

2. There is a higher mortality rate in extremely preterm infants when a low target oxygen saturation (85 to 89%) is used.

RELATED REPORTS

St. Louis hospital-based violence intervention program did not significantly affect reinjury outcomes

Glucagon-like peptide-1 receptor agonists may increase risk of reflux in patients with type 2 diabetes

Vaporized nicotine products may be effective for smoking cessation among people with social disadvantage

This study compared different methods of oxygenation in extremely preterm infants in the NICU. Authors found that noninvasive CPAP could be used as an alternative to early intubation with surfactant administration. However, since lower oxygenation groups had a higher rate of mortality, higher oxygenation saturation targets are recommended for infants who are extremely preterm.

The strengths of this study are the large sample size and the high follow up rate. The limitations of this study are that the results are based only upon a single visit and that disabilities may not be unearthed until later childhood.  

Click to read the study in NEJM

[/tab]

[tab]

Image: PD

1. Continuous Positive Airway Pressure (CPAP) can be used as an alternative to early intubation with surfactant administration in extremely preterm infants in the NICU.

2. There is a higher mortality rate in extremely preterm infants when a low target oxygen saturation (85 to 89%) is used.

Primer: With improvements in ventilation and creation of exogenous surfactants, infants born at 24 weeks of age can survive in the neonatal intensive care units (NICU). However, these extremely premature infants are at higher risk of death and developing neurological disorders such as intellectual delay, blindness, and cerebral palsy. Although lifesaving, early intubation with surfactant administration can lead to bronchopulmonary dysplasia due to mechanical scarring and high oxygen radicals. The purpose of the SUPPORT Trial was to compare the use of non-invasive continuous positive airway pressure (CPAP) on extremely premature infants to intubation with surfactant administration. Infants at 36 weeks showed no differences in the rates of death or bronchopulmonary dysplasia. The results at the corrected age of 18 to 22 months are reported in this study.

Background reading: 

  1. Neurologic and developmental disability after extremely preterm birth.
  2. Early CPAP versus surfactant in extremely preterm infants.

 

This [double blind, randomized control] study compared the use of CPAP to early intubation with surfactant administration with high and low oxygen saturation (85-89% vs. 91 to 95%) in 1316 extremely preterm infants, after 18 to 22 months.

Overall mortality did not differ between the CPAP and surfactant group. However, the lower oxygenation group had a significantly higher mortality rate than the higher oxygenation group. Furthermore, infants in the lower gestational-age stratum had a higher mortality in the surfactant group compared to the CPAP group. There were also no differences in the frequency of neurological development between any of the groups.

In sum: This study compared different methods of oxygenation in extremely preterm infants in the NICU. They found that noninvasive CPAP could be used as an alternative to early intubation with surfactant administration. However, since lower oxygenation groups had a higher rate of mortality, higher oxygenation saturation targets are recommended for infants who are extremely preterm.

The strengths of this study are the large sample size and the high follow up rate. The limitations of this study are that the results are based only upon a single visit and that disabilities may not be unearthed until later childhood.  

Click to read the study in NEJM

By [JC] and [MS]

© 2012 2minutemedicine.com. All rights reserved. No works may be reproduced without written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No post should be construed as medical advice and is not intended as such by the authors or by 2minutemedicine.com. PLEASE SEE A HEALTHCARE PROVIDER IN YOUR AREA IF YOU SEEK MEDICAL ADVICE OF ANY SORT. Content is produced in accordance with fair use copyrights solely and strictly for the purpose of teaching, news and criticism. No benefit, monetary or otherwise, is realized by any participants or the owner of this domain. 

[/tab]

[/tabs]

Previous Post

[Physician Comment] Pneumocystis linked to Sudden Unexpected Infant Deaths

Next Post

[Physician Comment] SSRI use during pregnancy not associated with fetal, neonatal or infant mortality

RelatedReports

Quick Take: Efficacy of prehospital criteria in identifying trauma patients susceptible to undertriage
Emergency

St. Louis hospital-based violence intervention program did not significantly affect reinjury outcomes

July 14, 2025
Unenhanced magnetic resonance imaging highly sensitive and specific for acute appendicitis
All Specialties

Glucagon-like peptide-1 receptor agonists may increase risk of reflux in patients with type 2 diabetes

July 14, 2025
Smoking during pregnancy associated with aerobic fitness of children
Public Health

Vaporized nicotine products may be effective for smoking cessation among people with social disadvantage

July 14, 2025
#VisualAbstract: Brain Activation Measured on Functional MRI Predicts Response to Certolizumab, a TNF Inhibitor, in Rheumatoid Arthritis
StudyGraphics

#VisualAbstract: Brain Activation Measured on Functional MRI Predicts Response to Certolizumab, a TNF Inhibitor, in Rheumatoid Arthritis

July 14, 2025
Next Post

[Physician Comment] SSRI use during pregnancy not associated with fetal, neonatal or infant mortality

Regional increases in unemployment in infancy associated with development of behavioral problems

Community hospitals rely on greater CT use to diagnose pediatric appendicitis

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • St. Louis hospital-based violence intervention program did not significantly affect reinjury outcomes
  • Glucagon-like peptide-1 receptor agonists may increase risk of reflux in patients with type 2 diabetes
  • Vaporized nicotine products may be effective for smoking cessation among people with social disadvantage
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.