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Home All Specialties Cardiology

Daily low dose aspirin may be associated with increased fall risk for geriatric patients

byDavy LauandAlex Chan
November 17, 2022
in Cardiology, Chronic Disease, Hematology
Reading Time: 2 mins read
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1. For healthy elderly patients randomized to take low-dose aspirin for 4 weeks, there was no difference in occurrence of fractures, but a higher occurrence of serious falls prompting hospitalization, compared to patients taking placebo.

Evidence Rating Level: 1 (Excellent)

For elderly patients, falls and fractures are a major contributor to morbidity and mortality with 700,000 deaths associated with falls globally each year. Falls can be attributed to both environmental and physiologic factors, such as bone strength. Although a systematic review has found an association between taking aspirin and lower odds of fracture, this has not yet been investigated in randomized controlled trials. Therefore, the ASPREE-FRACTURE study was initiated in Australia. This was a double-blind trial, comparing fall and fracture outcomes for otherwise healthy individuals aged 70 and older, randomized to take low-dose 100 mg aspirin or placebo, for 4 weeks. The measured outcomes included prevalence of fracture and serious falls prompting presentation to hospital. In total, there were 16,703 participants, 55.0% women, with 8,322 randomized to aspirin and 8,381 to placebo. The median (IQR) age was 74 (72-78) years, and the median follow-up was 4.6 years. The study found 2,865 fractures and 1,688 serious falls. There was no significant difference in the occurrence of first fractures (hazards ratio 0.97, 95% CI 0.87-1.06, p = 0.50) or recurrent fractures (HR 0.96, 95% CI 0.87-1.06, p = 0.40). However, more individuals in the aspirin group experienced serious falls, with 750 (9.0%) compared to 687 (8.2%), which was significantly different (incidence rate ratio 1.17, 95% CI 1.03-1.33, p = 0.01). Overall, this study demonstrated that healthy elderly patients taking low-dose aspirin had no difference in occurrence of fractures, but did have a significantly higher occurrence of serious falls.

Click to read the study in JAMA Internal Medicine

Image: PD

©2022 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

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