• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Gastroenterology

Higher abundance of dietary sulfur-reducing microbes was associated with increased risk of colorectal cancer

byYidi WangandAvneesh Bhangu
January 4, 2022
in Gastroenterology, Wellness
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. In this study, long-term high sulfur microbial diet was associated with increased risk of colorectal cancer.

2. Body weight and family history of colorectal cancer did not modify association between high sulfur microbial diet and colorectal cancer risk.

Evidence Rating Level: 2 (Good)

A diet high in low-calorie beverages and animal protein and fat has been thought to potentially increase intestinal sulfide production by gut microbiota and consequently increase the risk of colorectal cancer (CRC). However, the role of gut microbes that reduce dietary sulfur to potentially carcinogenic hydrogen sulfide in modulating risk of CRC has not been extensively tested.

This study pooled data from three prospective cohort studies of 214,797 adult male (40-74 years old) and female (25 to 55 years old) United States (US) health professionals, in which dietary intake was assessed using semi-quantitative food frequency questionnaire (FFQ) starting from 1986, 1984, and 1991. Participants who had a prior diagnosis of CRC, inflammatory bowel disease, or other cancers were excluded. Stool samples were collected from select group of participants (developmental cohort) from 2012-2014 and sequenced to identity gut microbiota composition. The relative abundance of 43 previously identified sulfur-metabolizing bacteria was determined in the 519-participant developmental cohort. The primary outcome was incidence of CRC, which was determined based on self-reported diagnosis of CRC in biennial questionnaires, medical records, tumor registries, and death certifications.

In this study, greater adherence to sulfur microbial diet was associated with increased risk of CRC (hazard ratio 1.27) and particularly, distal CRC (hazard ratio of 1.25). Overall, long-term adherence to sulfur microbial diet was associated with higher abundance of sulfur-metabolizing gut bacteria and increased risk of CRC. However, this study was limited in its homogenous study population of US health professionals which minimized sociodemographic confounding, warranting further study. Nonetheless, this study was significant in suggesting that adherence to a sulfur microbial diet (including red meats, low intake of fruits, whole grains, vegetables) is associated with increased risk of CRC.

Click to read the study in JAMA Network Open

RELATED REPORTS

Detection of advanced colorectal neoplasia by CT colonography comparable to optical colonoscopy [Classics Series]

Improved diet quality may be associated with increased longevity and better aging in Israeli adults

Subsidization of supermarkets may help reduce obesity risk in children

Image: PD

©2021 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: colorectal cancerdietfruitgut microbesmicrobesred meatsulfurvegetablewhole grain
Previous Post

Mediterranean diet and mindfulness-strategies reduced risk of low-birth-weight newborns

Next Post

#VisualAbstract: Hereditary retinoblastoma survivors are at an increased risk for melanoma and non-melanoma skin cancers

RelatedReports

The ABCD2 score: Risk of stroke after Transient Ischemic Attack (TIA) [Classics Series]
Radiology Classics

Detection of advanced colorectal neoplasia by CT colonography comparable to optical colonoscopy [Classics Series]

August 11, 2022
Improved glycemic control in type 1 diabetics on very low-carbohydrate diets
Wellness

Improved diet quality may be associated with increased longevity and better aging in Israeli adults

June 28, 2022
Meeting families, demographic information affect child abuse work-up
Pediatrics

Subsidization of supermarkets may help reduce obesity risk in children

June 27, 2022
Eating in the absence of hunger linked to toddler obesity
Pediatrics

Intensive program to support caretaker access to food improves diet of children

June 24, 2022
Next Post
#VisualAbstract: Hereditary retinoblastoma survivors are at an increased risk for melanoma and non-melanoma skin cancers

#VisualAbstract: Hereditary retinoblastoma survivors are at an increased risk for melanoma and non-melanoma skin cancers

Stent type may not be related to adverse cardiac events after surgery

Drug-eluting stents reduced in-stent restenosis risk for high-grade intracranial atherosclerotic stenosis lesions compared to bare-metal stents

Quick Take: Effect of Pregabalin on Radiotherapy-Related Neuropathic Pain in Patients With Head and Neck Cancer: A Randomized Controlled Trial

No significant association between maternal hormonal contraception use and central nervous system tumors in children

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • LI-RADS outlines standards for liver imaging studies assessing HCC [Classics Series]
  • Daily disposable contact lenses may lower risk for Acanthamoeba keratitis
  • Vitamin D deficiency may be associated with sleep disorders in children
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.