Tag: colorectal cancer

1. A phase 3 randomized clinical trial showed that combined therapy using a BRAF inhibitor (encorafenib), EGFR monoclonal antibody (cetuximab) and a MEK inhibitor (binimetinib) led to longer overall disease survival in patients with BRAF V600E mutated metastatic colorectal cancer as compared to control groups who received a single...

1. A phase 3 randomized clinical trial showed that combined therapy using a BRAF inhibitor (encorafenib), EGFR monoclonal antibody (cetuximab) and a MEK inhibitor (binimetinib) led to longer overall disease survival in patients with BRAF V600E mutated metastatic colorectal cancer as compared to control groups who received a single...

1. In this microsimulation model of U.S. patients aged 50-79, high-intensity surveillance following colorectal adenoma provided clinically significant benefits over low-intensity surveillance at acceptable cost. 2. In nearly all evaluated alternative scenarios, the absolute cost-effectiveness of high-intensity surveillance remained under $100,000 per quality-adjusted life-year (QALY) gained. Compared with low-intensity surveillance,...

1. In this microsimulation model of U.S. patients aged 50-79, high-intensity surveillance following colorectal adenoma provided clinically significant benefits over low-intensity surveillance at acceptable cost. 2. In nearly all evaluated alternative scenarios, the absolute cost-effectiveness of high-intensity surveillance remained under $100,000 per quality-adjusted life-year (QALY) gained. Compared with low-intensity surveillance,...

1. In this randomized controlled trial, cold snare polypectomy with continuous anticoagulation does not increase bleeding risk when compared to hot snare polypectomy with heparin bridging. 2. The cold snare polypectomy procedure had shorter procedure time per lesion and decreased length of hospital stays in comparison to hot snare polypectomy. Evidence...

1. In this randomized controlled trial, cold snare polypectomy with continuous anticoagulation does not increase bleeding risk when compared to hot snare polypectomy with heparin bridging. 2. The cold snare polypectomy procedure had shorter procedure time per lesion and decreased length of hospital stays in comparison to hot snare polypectomy. Evidence...

Patients with colorectal cancer (CRC) are 2-4 times more likely to develop cardiovascular disease, as compared to individuals without a history of cancer. With survival rates increasing significantly over the last 4 decades, this has important implications in patients that are now more susceptible to competing causes of morbidity...

Association between incidence exposure to benzodiazepines in early pregnancy and risk of spontaneous abortion Previous studies have shown that benzodiazepine use in early pregnancy is associated with spontaneous abortion (SA). The association between specific benzodiazepines and the risk of SA, however, has not been investigated. In this nested case-control study...

For patients with rectal cancer, the strongest predictor of local recurrence is the circumferential resection margin (CRM) after surgery, with negative CRMs being the goal. Current guidelines recommend preoperative chemoradiotherapy (CRT) before surgery, as this has been shown to decrease the rate of local recurrence. CRT, however, is associated...

Safety and Feasibility of Using Magnetic Resonance Imaging Criteria to Identify Patients With “Good Prognosis” Rectal Cancer Eligible for Primary Surgery: The Phase 2 Nonrandomized QuickSilver Clinical Trial For patients with rectal cancer, the strongest predictor of local recurrence is the circumferential resection margin (CRM) after surgery, with negative CRMs...