Tag: colorectal cancer

1. Incomplete resection of colon segments was shown to significantly increase the risk of future neoplasia compared to segments with complete resection. 2. Advanced neoplasia was shown to be more likely in incomplete segment resections compared to complete resections. Evidence Rating Level: 2 (Good) Study Rundown: An estimated account of incomplete polyp...

1. Patients on adavosertib had both increased progression-free survival and better tumor control, as compared to patients being actively monitored only. 2. Overall survival was not affected by adavosertib as compared to active monitoring, but a subgroup analysis showed an increase in survival for patients with a left-sided primary compared...

1. Progression-free survival was extended by the use capecitabine as compared to active monitoring, but at the expense of increased toxicity. There was no difference in overall survival between treatment arms. 2. Quality of life scores were similar between the two treatment arms. Evidence Rating Level: 1 (Excellent) Study Rundown: Current standards...

1. In this retrospective cohort study investigating targeted therapy of programmed cell death receptor 1 and programmed cell death ligand 1 in the treatment of microsatellite stable (MSS) metastatic colorectal cancer with and without liver metastases, targeted therapy was found to be effective in patients without liver metastases, but...

1. Although combining pembrolizumab to chemoradiotherapy as part of total neoadjuvant therapy after FOLFOX (5-fluorouracil, leucovorin, and oxaliplatin) treatment was safe overall, the difference in neoadjuvant rectal score does not support further study of this novel combination for the treatment of locally advanced rectal cancer. 2. These results and the...

1. Adding celecoxib to adjuvant chemotherapy did not increase disease-free survival or overall survival compared to placebo in patients with stage III colon cancer. 2. Celecoxib treatment led to increased incidence of hypertension and elevated levels of creatinine versus placebo. Evidence Rating Level: 1 (Excellent) Study Rundown: Aspirin and cyclooxygenase 2 (COX-2)...

1. Explicit emulation of a target trial investigating the comparative efficacy of a shortened duration of adjuvant chemotherapy in individuals with stage III colon cancer was found to be noninferior to the standard 6-month regimen, consistent with results from the International Duration Evaluation of Adjuvant (IDEA) trial. 2. In contrast,...

1. Low- and middle-income countries have a higher 30-day mortality in colorectal and gastric cancer surgeries compared with high-income countries. 2. Although the rate of peri-operative complications was similar across all country income levels, patients in low or lower-middle income countries were more likely to die from these events. Evidence Rating...

1. While carcinoids contribute more heavily to the total incidence of early-onset colorectal cancer than they did in 2000, adenocarcinomas have also become more prevalent in nearly all subgroups. 2. Younger patients are experiencing the greatest growth in incidence rate, highlighting the necessity of risk-stratification and early diagnostic testing. Evidence Rating...

1. In a phase 3 trial across 23 countries, Pembrolizumab displayed a longer cancer-free period when compared to the first line therapy for metastatic microsatellite instability or mismatch-repair deficiency (MSI-H-dMMR) colorectal cancer. Evidence Rating Level: 1 (Excellent) Study Rundown: A subset of colorectal cancer tumors is mismatch-repair deficiency (dMMR) which has been known...