• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Hybrid closed-loop therapy improves glycemic control for children with Type 1 Diabetes

byDavid XiangandHarsh Shah
January 31, 2022
in Chronic Disease, Endocrinology, Pediatrics
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. In very young children with type 1 diabetes, a hybrid closed-loop therapy provided significantly improved glycemic children.

2. The hybrid closed-loop therapy did not significantly increase the time spent in hypoglycemia in very young children with type 1 diabetes.

Evidence Rating Level: 1 (Excellent)

Study Rundown: In very young children, managing Type 1 Diabetes is difficult due to the high variability of insulin requirements and challenges in maintaining recommended glycemic control without constant caregiver monitoring. Hybrid closed-loop systems (also known as an artificial pancreas) offer an algorithm that automatically adjusts insulin delivery based on real-time sensory glucose levels and improves glycemic control in older children and adolescents, but there is a gap in knowledge as to understanding its effectiveness in improving glycemic control for very young children. This study found that the hybrid closed-loop system significantly improved glycemic control, as compared to sensor-augmented pump therapy, in children aged 1 to 7 with type 1 diabetes. This study was limited by the characterization of research participants as those who participate in closed-loop studies tend to be highly motivated, which limits generalizability. Nevertheless, these study’s findings are significant, as they demonstrate that hybrid closed-loop insulin therapy provides significant improvements in glycemic control in very young children with type 1 diabetes.

Click to read the study in NEJM

Relevant Reading: Reducing Caretaker Burden, Protecting Young Brains and Bodies

In-Depth [randomized control trial]: This randomized control trial included 74 participants at seven centers across Austria, Germany, Luxembourg, and the United Kingdom. Patients aged 1 to 7, with the diagnosis of type 1 diabetes at least 6 months before enrollment, and glycated hemoglobin level of no more than 11% were eligible. Patients who were currently using closed-loop therapy or those with concomitant disease affecting metabolic control were excluded from the study. Patients received two 16-week treatment periods in random order, in which the hybrid closed-loop system was compared with the sensor-augmented pump therapy (control treatment). The primary outcome measured was the between-treatment difference in the percentage of time spent in the target glucose range during each 16-week period. Outcomes in the primary analysis were assessed on an intention-to-treat basis and compared with a repeated-measures linear mixed model. Between the two treatment groups, the percentage of time with glucose level in the target range was 8.7% higher when patients were using the hybrid closed-loop system as opposed to the control (95% confidence interval [CI], 7.4 to 9.9). The mean adjusted difference (closed-loop minus control) in the percentage of time spent in a hyperglycemic state was -8.5% (95% CI, -9.9 to -7.1). The time spent in a hypoglycemia state did not differ significantly between the two treatment groups (p-value = 0.74). Overall, this study demonstrated that closed-loop insulin delivery provided significant improvement in glycemic control in very young children with type 1 diabetes over a treatment period of 16 weeks.

RELATED REPORTS

Wellness Check: Nutrition

Melatonin improves sleep onset in children with autism spectrum disorder

Wellness Check: Sleep

Image: PD

©2022 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: artificial pancreaschildrenglycemic controlHybrid closed-loop therapyhyperglycemic statehypoglycemic statetype 1 diabetes
Previous Post

Physical activity has a weight-independent effect on mortality

Next Post

BRCA1/2 pathogenic variants are associated with an increased risk of male breast, pancreatic, and stomach cancer.

RelatedReports

Improved glycemic control in type 1 diabetics on very low-carbohydrate diets
Wellness

Wellness Check: Nutrition

January 26, 2023
Parents with poor sleep quality report sleep problems in kids
Pediatrics

Melatonin improves sleep onset in children with autism spectrum disorder

January 23, 2023
Decline in adolescent sleep duration over past 20 years
Wellness

Wellness Check: Sleep

January 19, 2023
AAP recommends disaster preparedness measures for children
Health

Transform-Us! reduces sedentary behavior and adiposity indicators in children

January 4, 2023
Next Post
Maternal cell-free DNA sequencing superior to standard aneuploidy screening [CARE Study]

BRCA1/2 pathogenic variants are associated with an increased risk of male breast, pancreatic, and stomach cancer.

Recurrence of endometrial hyperplasia following medical therapy is common

Lenvatinib plus pembrolizumab increased survival for advanced endometrial cancer patients when compared to chemotherapy

Quick Take: Left ventricular mechanical dispersion predicts arrhythmic risk in mitral valve prolapse

Tricuspid repair in patients with mitral regurgitation offers clinical benefits

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • BNT162b2 booster is safe and reduces COVID-19 transmission in older adults
  • Bisphosphonates, denosumab, abaloparatide, teriparatide, and romosozumab reduce postmenopausal fracture risk
  • Epstein-Barr viral load monitoring reduces risk of post-liver transplant lymphoproliferative disease
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options