Tag: type 1 diabetes

1. Patients who used continuous glucose monitoring (CGM) showed significantly reduced glycated hemoglobin (HbA1C) levels compared to those who used standard blood glucose monitoring (BGM) after 26 weeks. 2. On average, patients in the CGM group spent more time in the target glucose range (70-180 mg/dL) compared to those in...
1. Serum urate reduction with allopurinol was not shown to clinically benefit kidney function among patients with type 1 diabetes and early-to-moderate diabetic kidney disease. 2. Serum creatinine did not improve following serum urate reduction with allopurinol. Evidence Rating Level: 1 (Excellent) Study Rundown: The lifetime risk of diabetic kidney disease among...
1. In this randomized controlled trial, patients with type 1 diabetes who used a closed-loop system spent a greater percentage of time in a target glycemic range compared to those who used a sensor-augmented insulin pump. 2. The closed-loop system was effective in reducing glycated hemoglobin level as well as...
1. In adolescents with type 1 diabetes mellitus, the albumin-to-creatinine ratio was not significantly changed by angiotensin-converting-enzyme (ACE) inhibitors alone, statins alone, or the two in combination compared to placebo. 2. In this population, ACE-inhibitors and statins did not demonstrate a significant benefit on other markers of diabetic vascular complications...
1. In a prospective study of children at-risk for development of type-1 diabetes, antibiotic use was not associated with the development of islet or celiac disease autoimmunity. 2. The investigators accounted for geography, which can be a major confounding variable. Evidence Rating Level: 2 (Good)        Study Rundown: The increased prevalence of autoimmune...
1. Risk of developing clinically significant diabetic retinopathy or macular edema over specified timeframes can be modeled using fundal exam and hemoglobin A1c (HbA1c) results for patients with type 1 diabetes (T1DM). 2. Modeled probabilities for development of retinopathy or macular edema can reduce frequency of eye exams while maintaining...
1. When compared to men with type 1 diabetes, women have a 37% greater excess risk of all-cause mortality 2. When compared to men with type 1 diabetes, women have twice the excess risk of fatal and nonfatal vascular events Evidence Rating Level: 1 (Excellent)       Study Rundown: Type 1 diabetes...
1. The age-adjusted incidence and prevalence of diabetes increased each year between 1990-2008, but has plateaued from 2008-2012. 2. However, certain groups remain disproportionately affected by diabetes, such as non-Hispanic blacks, Hispanic adults, and adults who have high school education or less. Evidence Rating Level: 2 (Good) Study Rundown: The association between obesity...
1. An average American born between 2000 and 2011 was estimated to have a 40% probability of developing diabetes during their lifetime.  2. The greatest lifetime risks were seen in Hispanic men and women and non-Hispanic black women, in which lifetime diabetes risks increased to over 50%. Evidence Rating Level: 3...
In this section, we highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Efficacy of paracetamol for acute low-back pain: a double-blind, randomised controlled trial Paracetamol (also known as acetaminophen) is commonly prescribed as a first-line agent for acute lower back pain, however its effectiveness...