• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Pediatrics

Increased survival without major morbidity noted among very low birthweight infants in California

byAlex Gipsman, MDandLeah Carr, MD
June 18, 2020
in Pediatrics
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. In a retrospective cohort study of almost 50 000 very low birth weight infants (VLBW), overall survival without major morbidity increased significantly between 2008 and 2017.

2. The largest improvements in major morbidity rates were seen for nosocomial infection (NI) and necrotizing enterocolitis (NEC), while the rates of bronchopulmonary dysplasia (BPD) and cystic periventricular leukomalacia (PVL) were unchanged.

Evidence Rating Level: 2 (Good)

Study Rundown: Very low birthweight (VLBW) infants, those born at <1500g, are at increased risk for serious morbidity and death from a multitude of causes. Although California has taken a collaborative approach to examining efforts aimed at reducing these complications, no long-term evaluation of survival without major morbidity in this system has been completed. This retrospective cohort study analyzed long-term survival without major morbidity among VLBW infants across 142 NICUs in California between 2008 and 2017. Major morbidity was defined as infant death occurring during birth hospitalization, BPD, severe intraventricular hemorrhage (IVH), NI, NEC, severe retinopathy of prematurity (ROP), and cystic PVL. During the study period, overall survival without major morbidity improved, however rates of BPD and PVL were unchanged. There was also a significant decrease in variation of survival without major morbidity between hospitals. It was noted that if all hospitals performed as well as those in the top quartile, there would have been an additional 6.6% improvement per year in overall survival without major morbidity. Overall, the study highlights important achievements in neonatal care of VLBW infants as well as potential areas for continued improvement.

Click to read the study, published today in Pediatrics

Click to read an accompanying editorial in Pediatrics

In-Depth [retrospective cohort]: The study population included infants born between 2008 and 2017 with a birth weight between 401 to 1500 grams or a gestational age between 22 and 29 weeks from 142 NICUs in the California Perinatal Quality Care Collaborative (CPQCC). The median gestational age was 28 weeks (IQR 26-30 weeks). Infants with severe congenital anomalies and those who died in the delivery room were excluded. A total of 49 333 infants (51.9% male, 45.1% Hispanic) were included in the final analysis. Overall survival without major morbidity improved by 7.6% (p < 0.001), while rates of BPD and PVL were unchanged. The largest change was seen among infants <25 (18.7% improvement) and 25-27 (16.5%) weeks’ gestation. Trends in individual morbidities were also examined; the largest improvements were seen in NI (44.7% decreased incidence, p < 0.001) and NEC (-45.6%, p < 0.001). Statistically significant improvements were also seen in severe ROP (-36.4%, p < 0.001) and IVH (-20.4%, p < 0.001). Rates of PVL and BPD were not significantly changed during the study period. In infants who survived with a major morbidity, the number of morbidities decreased over time.

RELATED REPORTS

Resuscitation practices in moderate and late preterm infants are highly variable

Patterns of anti-VEGF treatment for retinopathy of prematurity vary by country

Adjuvant erythropoietin therapy does not improve survival in newborns with hypoxic-ischemic encephalopathy

Image: PD

©2020 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: bronchopulmonary dysplasia (BPD)necrotizing enterocolitisneonatologyretinopathy of prematurity (ROP)
Previous Post

Empiric systemic tuberculosis treatment not superior to test-guided treatment for HIV patients

Next Post

Rifampin viable as an alternative to isoniazid treatment for latent tuberculosis

RelatedReports

Increasing C-section room temperature linked to reduced neonatal, maternal hypothermia
Pediatrics

Resuscitation practices in moderate and late preterm infants are highly variable

August 1, 2022
Head circumference better predicts labor dystocia than weight
Ophthalmology

Patterns of anti-VEGF treatment for retinopathy of prematurity vary by country

July 25, 2022
Increasing C-section room temperature linked to reduced neonatal, maternal hypothermia
Emergency

Adjuvant erythropoietin therapy does not improve survival in newborns with hypoxic-ischemic encephalopathy

July 19, 2022
Large proportion of late preterm infants and older admitted to the NICU
Infectious Disease

Maternal vaccination linked to lower coronavirus disease-related hospitalizations in infants

July 19, 2022
Next Post
Quick Take: Discovery and validation of a prognostic proteomic signature for tuberculosis progression

Rifampin viable as an alternative to isoniazid treatment for latent tuberculosis

Increasing maternal BMI linked to higher risk of cerebral palsy

Psychosocial, behavioral and clinical correlates of children with overweight and obesity

#VisualAbstract: Patterns of Influenza Vaccination and Vaccine Effectiveness Among US Children

#VisualAbstract: Patterns of Influenza Vaccination and Vaccine Effectiveness Among US Children

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Management of uncomplicated urinary tract infections amongst women in the United States Military Health System highly concordant with guidelines
  • Gout flares associated with a transient increase in subsequent risk of cardiovascular events
  • Litifilimab associated with reduced disease severity in patients with cutaneous lupus erythematosus
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.