• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Long-term glucosamine sulfate likely improves pain and function in knee osteoarthritis

byDaniel Fisher
January 1, 2019
in Chronic Disease, Surgery
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. In this systematic review and meta-analysis of patients with knee osteoarthritis (OA) receiving a variety of pharmacologic treatments, glucosamine sulfate was associated with improvement in long-term pain.

2. Glucosamine sulfate was also associated with better physical functioning and joint space narrowing.

Evidence Rating Level: 1 (Excellent)

Study Rundown: There are many treatments for osteoarthritis (OA), which is the most common cause of disability worldwide, including NSAIDs, antioxidants, opioids, glucosamines, bone acting agents, and intraarticular injections. Despite ample research suggesting effective subacute treatments, the use of these strategies for long-term OA pain control is less clear. In this systemic review and meta-analysis, only glucosamine sulfate resulted in significant long-term knee OA pain reduction. Celecoxib was associated with reduced pain in initial analyses, but did not differ when normalizing pain scales and accounting for studies with high risk of bias. Similarly, glucosamine sulfate was associated with improvement in function and joint space narrowing.

While this study highly suggests that glucosamine sulfate is a viable long-term treatment strategy for knee OA, it did not exclude other treatments as being beneficial. On the contrary, the high degree of uncertainty in measurements and large number of treatments surveyed represents significant limitations in statistical power that is likely to diminish the authors’ abilities to detect other truly beneficial treatments, such as NSAIDs.

Click to read the study in JAMA

Relevant Reading: Treatment of osteoarthritis of the knee: an update review

RELATED REPORTS

#VisualAbstract: High-dose exercise therapy is not superior to low-dose exercise therapy for knee osteoarthritis

Exercise may be as effective as pharmacotherapy in managing osteoarthritis pain

High-dose exercise therapy is not superior to low-dose exercise therapy for knee osteoarthritis

In-Depth [systematic review and meta-analysis]: 47 randomized controlled trials involving 22,037 patients were included in this analysis which evaluated the long-term (>1 year) effects of 31 different interventions including analgesics, NSAIDs, glucosamine derivatives, antioxidants, bone-acting agents, intraarticular injections, corticosteroids, and disease modifying agents. The preferred pain outcome measure was the subscale of the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) while the physical function outcome measure was also prioritized for the WOMAC. Of the 47 included trials, 32 were placebo controlled. There was a large degree of uncertainty surrounding all measurements. Only 2 out of the 31 interventions were associated with significantly improved pain, glucosamine sulfate (Standardized Mean Difference -0.29; CI95 -0.49 to -0.09) and celecoxib (SMD -0.18; CI95 -0.35 to -0.01). When data was analyzed as a mean difference on a scale from 0 to 100, only glucosamine sulfate remained significant (mean difference -4.07; CI95 -6.99 to -1.18). Removing trials with high risk of bias similarly only revealed a difference for glucosamine sulfate (SMD -0.29; CI95 -0.49 to -0.10). Compared with placebo, only glucosamine sulfate was associated with improved physical functioning (SMD -0.32; CI95 -0.52 to -0.12). Three interventions were associated with improved joint space narrowing: glucosamine sulfate (SMD -0.42; CI95 -0.65 to -0), chondroitin sulfate (SMD -0.20; CI95 -0.31 to -0.07), and strontium ranelate (SMD -0.20; CI95 -0.36 to -0.05).

Image: PD

©2018 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: chondroitin sulfateglucosamine sulfateosteoarthritis
Previous Post

2 Minute Medicine Rewind December 31, 2018

Next Post

Quick Take: Risk of Depression and Anxiety in Adults With Cerebral Palsy

RelatedReports

StudyGraphics

#VisualAbstract: High-dose exercise therapy is not superior to low-dose exercise therapy for knee osteoarthritis

February 16, 2023
Wide-ranging health benefits from outdoor adult walking groups
Chronic Disease

Exercise may be as effective as pharmacotherapy in managing osteoarthritis pain

February 6, 2023
Physical therapy reduces pain in adults with knee osteoarthritis
Chronic Disease

High-dose exercise therapy is not superior to low-dose exercise therapy for knee osteoarthritis

February 3, 2023
Few older adolescents meet recommended levels of physical activity
Wellness

Wellness Check: Exercise

February 2, 2023
Next Post
Shared decision-making tool for antidepressants improves patient and physician satisfaction

Quick Take: Risk of Depression and Anxiety in Adults With Cerebral Palsy

Variability in interpretation of breast biopsy slides associated with low verification of atypia and ductal carcinoma in situ

Quick Take: Neoadjuvant degarelix versus triptorelin in premenopausal patients who receive letrozole for locally advanced endocrine-responsive breast cancer: a randomized phase II trial

Addressing non-obesity related barriers may improve bariatric surgery effectiveness

Revisional surgeries common after bariatric surgery

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Mycobacterium abscessus infections after cardiac surgery linked to hospital water system
  • The 2 Minute Medicine Podcast Episode 11
  • Wellness Check: Spirituality
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options