Tag: osteoarthritis

1. Among a cohort of patients with knee osteoarthritis, a web-based intervention of self-directed strengthening exercises and activity guidance supported with automated text messaging improved both pain and functional capacity at 24 weeks. Evidence Rating Level: 1 (Excellent) Osteoarthritis (OA) of the knee is highly prevalent and has no known cure;...
1. Patients with a body mass index (BMI) of 40 kg/m2 or greater who had total knee replacement surgery improved quality-adjusted life expectancy at an acceptable cost. 2. Treatment was less cost-effective for older patients and those with prognostically important comorbidities such as diabetes and cardiovascular disease. Evidence Rating Level: 2...
1. 5 and 10 years after undergoing a high tibial osteotomy procedure, 95% and 79% of knee osteoarthritis patients respectively did not require a total knee replacement. 2. Preoperative factors associated with an increased rate of conversion to total knee replacement included greater radiographic severity, female sex, greater knee pain,...
1. A hospital with “better than expected” outcomes for implant survival in total hip replacement (THR) used the Exeter V40 femoral stem implant on all patients. 2. No difference in implant survival was found between this hospital and other hospitals, when examining only cases with the Exeter V40 femoral stem. Evidence...
1. Physical therapy was shown to significantly reduce pain in patients with knee osteoarthritis compared to the patients who received an intraarticular glucocorticoid injection. 2. Physical therapy significantly improved functionality compared to treatment with an intraarticular glucocorticoid injection for osteoarthritis of the knee. Evidence Rating Level: 1 (Excellent) Study Rundown: Osteoarthritis of...
1. In this double-blind phase 2a trial, cathepsin K inhibitor MIV-711 did not show a significant benefit in reducing pain but proved effective in delaying structural changes associated with progression of osteoarthritis. 2. Biomarkers of bone resorption were significantly reduced in both treatment groups but returned to baseline levels after...
1. In this double-blind phase 2a trial, cathepsin K inhibitor MIV-711 did not show a significant benefit in reducing pain but proved effective in delaying structural changes associated with progression of osteoarthritis. 2. Biomarkers of bone resorption were significantly reduced in both treatment groups but returned to baseline levels after...
1. In this randomized controlled trial, subcutaneous tanezumab resulted in moderate improvements in joint pain and physical function for patients with osteoarthritis compared to placebo. 2. Tanezumab-treated patients had more adverse events and more joint replacements. Evidence Rating Level: 1 (Excellent) Study Rundown: Nerve growth factor (NGF) is involved in pain signaling during...
The two main surgical options for late-stage medial compartment osteoarthritis of the knee are partial knee replacement (PKR) and total knee replacement (TKR). There is significant variation in choice of approach among surgeons, likely because randomized controlled trials comparing the two approaches have not been performed. In this multicenter,...
1. In this randomized controlled trial, subcutaneous tanezumab resulted in moderate improvements in joint pain and physical function for patients with osteoarthritis compared to placebo. 2. Tanezumab-treated patients had more adverse events and more joint replacements. Evidence Rating Level: 1 (Excellent) Study Rundown: Nerve growth factor (NGF) is involved in pain signaling...