Tag: osteoarthritis

1. In this retrospective cohort of patients with osteoarthritis, tramadol had a significantly higher risk of mortality over 1 year compared to NSAIDs, though there were many confounding factors precluding determination of a causal relationship. 2. No differences in mortality were found when comparing tramadol and codeine. Evidence Rating Level: 2...
1. In this retrospective cohort of patients with osteoarthritis, tramadol had a significantly higher risk of mortality over 1 year compared to NSAIDs, though there were many confounding factors precluding determination of a causal relationship. 2. No differences in mortality were found when comparing tramadol and codeine. Evidence Rating Level: 2...
1. In this systematic review and meta-analysis of patients with knee osteoarthritis (OA) receiving a variety of pharmacologic treatments, glucosamine sulfate was associated with improvement in long-term pain. 2. Glucosamine sulfate was also associated with better physical functioning and joint space narrowing. Evidence Rating Level: 1 (Excellent) Study Rundown: There are many...
1. Intra-articular fractures (IAFs) often lead to posttraumatic osteoarthritis (PTOA) through mechanisms that involve mitochondria. 2. In a porcine model of IAF, inhibition of mitochondrial electron transport and oxidative stress with amobarbital or N-acetylcysteine (NAC) slowed progression of posttraumatic osteoarthritis. Evidence Rating Level: 2 (Good) Study Rundown: PTOA is the progressive destruction...
1. For radiographic osteoarthritis and hand pain that is moderate to severe, hydroxychloroquine (HCQ) does not show any greater effectiveness than placebo for reducing overall hand pain. 2. There was also no significant difference between HCQ and placebo for secondary end points including function, grip strength, radiographic structural damage, and...
1. In this double blind, randomized controlled trial, intra-articular triamcinolone injections did not prevent cartilage degeneration compared to saline injection controls. 2. Triamcinolone injections did not improve patients’ pain from osteoarthritis compared to controls. Evidence Rating Level: 1 (Excellent) Study Rundown: Osteoarthritis is a leading cause of disability in the United States....
1. Significantly greater pain improvement was observed in patients in the intervention group compared to the control. 2. Patients in the pain-control intervention group demonstrated significant improvement in physical function. Evidence Rating Level: Excellent (1) Study Rundown: Osteoarthritis (OA) is a major cause of chronic knee pain, leading to global disability among...
1. No statistically significant improvement associated with combined patient and provider intervention in osteoarthritis patients compared to usual care. 2. Physical function and depressive symptoms were similar amongst both intervention and control patient groups. Evidence Rating Level: 1 (Excellent) Study Rundown: Osteoarthritis is a leading chronic health conditions in primary care settings....
1. Patients with arthritis treated with celecoxib experienced cardiovascular (CV) outcomes at a rate noninferior to those treated with ibuprofen or naproxen. 2. Celecoxib treated patients experienced adverse gastrointestinal events at a lower rate compared to patients treated with ibuprofen or naproxen. Evidence Rating: 1 (Excellent) Study Rundown: Nonsteroidal anti-inflammatory drugs (NSAIDs)...
1. A helper-dependent adenoviral vector (HDV) was modified with an antibody (a10mab) that specifically targeted molecules on the chondrocyte cell surface, in order to improve delivery of the proteoglycan 4 (PRG4) gene. 2. In a mouse model of osteoarthritis (OA), the targeted vector performed better than the non-targeted vector...