• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Longer preoperative treatment of advanced pancreatic cancer may extend survival

bys25qthea
December 5, 2013
in Chronic Disease, Endocrinology, Gastroenterology, Surgery
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

Image: PD 

1. Prolonged chemotherapeutic down-staging before resection was associated with improved survival in patients with previously inoperable pancreatic cancers. 

2. SMAD4 protein loss correlated significantly with overall survival.

Evidence Rating Level: 2 (Good)            

Study Rundown: Pancreatic cancer is one of the most deadly malignancies, and pancreatic ductal adenocarcinoma in particular has a 5.8% 5-year overall survival (OS. Patients with locally invasive disease may be treated with downstaging chemotherapy to reduce vascular involvement, but this approach is not yet standardized and produces variable results. In this study, the authors investigated the effect of a median 7.1 months (range 5.4-9.6 months) of chemotherapy before resection, and found 75.5% of patients to be lymph-node negative, with a median OS of 40.1 months (range 22.7-65.9 months). Additionally, multivariate modeling of prognostic biomarkers showed SMAD4 protein loss to affect OS. This study provides good evidence for modifying treatment practices for advanced pancreatic cancer, with plenty of pathologic and outcome data. A more detailed analysis of the effect of duration of chemotherapy on outcomes would be prudent, as the range spanned more than four months and may include a threshold.

Click to read the study in JAMA Surgery

RELATED REPORTS

Artificial Intelligence and Real World Data Speed Up Drug Development

Hypnotic drug use may be associated with increased risk of postoperative delirium

#VisualAbstract: Cabozantinib Improved Progression-Free Survival in Advanced Neuroendocrine 2m -m Tumors

Relevant Reading: Treatment options for advanced pancreatic cancer: a review

In-Depth [retrospective cohort study]: All patients from UCLA diagnosed from 1992-2011 with initially unresectable stage III pancreatic ductal adenocarcinoma who underwent resection after down-staging were included in the analysis (n=49). All patients were initially unresectable owing to tumor vascular involvement. Most received a multidrug regimen based on gemcitabine or 5-FU, and most also received a pylorus-sparing Whipple. Resolution of vascular involvement occurred in 15 patients. Most patients (75.5%) had lymph node-negative disease at time of resection, which correlated with longer survival. Patients with negative lymph nodes after resection may have experienced a longer duration of chemotherapy (this finding was not statistically significant). Recurrence occurred in 49% of cases, only 12.5% of which was local. SMAD4 and stromal miR-21 correlated with OS on univariate Cox analysis, but only SMAD-4 was significant in the multivariate model (HR 9.3, 95%CI 2.0-42.5, p=0.004).

By Mariya Samoylova and Allen Ho

More from this author: Resident involvement linked with more complications in joint surgery; Promising liver transplant outcomes at 20 years; Transfusion worsens outcomes for HCV+ liver transplant recipients; Endovascular repair of ruptured AAAs no better than open repair 

© 2012-2013 2minutemedicine.com. All rights reserved. No works may be reproduced without expressed written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No post should be construed as medical advice and is not intended as such by the authors, editors, staff or by 2minutemedicine.com. PLEASE SEE A HEALTHCARE PROVIDER IN YOUR AREA IF YOU SEEK MEDICAL ADVICE OF ANY SORT.  

Tags: pancreatic cancerpancreatic surgery
Previous Post

Imaging biomarkers may improve prediction of aortic valve stenosis

Next Post

Patients with late stage melanoma remain at risk for further primary melanoma

RelatedReports

AI Roundup

Artificial Intelligence and Real World Data Speed Up Drug Development

May 27, 2025
Post-surgical wound complications more common in obese ovarian cancer patients
Psychiatry

Hypnotic drug use may be associated with increased risk of postoperative delirium

March 13, 2025
#VisualAbstract: Perioperative Durvalumab with Neoadju-vant Chemotherapy Improved Survival in Operable Bladder Cancer
StudyGraphics

#VisualAbstract: Cabozantinib Improved Progression-Free Survival in Advanced Neuroendocrine 2m -m Tumors

October 1, 2024
The 2 Minute Medicine Podcast Episode 15
2MM Podcast

The 2 Minute Medicine Podcast Episode 16

June 1, 2023
Next Post
Patients with late stage melanoma remain at risk for further primary melanoma

Patients with late stage melanoma remain at risk for further primary melanoma

High BMI linked to reduced risk of endometriosis

“Benign obesity” perhaps not so benign

Gestational weight loss may improve outcomes for obese women

BMI, waist circumference associated with semen quality

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Sodium-glucose cotransporter 2 inhibitors may decrease risk of serious liver events in patients with cirrhosis
  • #VisualAbstract: Lactated Ringer’s Solution Does Not Improve Outcomes Relative to Normal Saline
  • 2MM: AI Roundup – FDA’s AI Push, Trial Speedups with Real-World Data, Smart Surgical Monitors, and Regulatory Overhaul Begins [July 2nd, 2025]
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.