Tag: pancreatic cancer

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1. Increased expression of the protein hemopexin in stroma of patients with pancreatic ductal adenocarcinoma may be associated with lymph node metastasis. Evidence Rating Level: 2 (Good) Pancreatic ductal adenocarcinoma (PDAC) has a 5-year survival rate of 7% and patients with lymph node metastases (≥4) have a 25% lower 5-year survival...
1. Randomized control trial of patients with metastatic pancreatic adenocarcinoma demonstrates that adjuvant therapy with a modified FOLFIRINOX regimen results in significantly longer disease-free survival and median overall survival rates as compared to traditional gemcitabine therapy. 2. Higher rates of adverse events were noted among patients randomized to the FOLFIRINOX...
Association between family characteristics and the effect of timing of regular egg introduction in infant egg allergy Recent studies have shown that the introduction of eggs early on in the diet is associated with reduced egg allergy. Infant feeding guidelines are also shifting to recommend that traditionally allergenic foods be...
Daratumumab, Lenalidomide, and Dexamethasone for Multiple Myeloma Daratumumab is a human monoclonal antibody that has shown efficacy and safety in phase 1 and 2 trials for patients with refractory or relapsed multiple myeloma. This phase 3 randomized trial investigated daratumumab as an adjunct to lenalidomide and dexamethasone in 569 patients...
1. The authors synthesized photoactivable multi-inhibitor nanoliposomes (PMILs), lipid nanoparticles that encapsulated the chemotherapeutic cabozantinib and released drug in response to light. 2. In mouse models of pancreatic ductal adenocarcinoma (PDAC), PMIL treatment led to a significant decrease in tumor size, microvascular proliferation, and metastasis. Evidence Rating Level: 2 (Good) Study...
1. In a randomized controlled trial of over 300 patients with advanced pancreatic cancer treated in the outpatient setting, the use of a combined regimen of chemotherapy and prophylactic enoxaparin demonstrated significant reduction in the incidence of symptomatic venous thrombotic events compared to chemotherapy alone. 2. The addition of prophylactic...
1. Following a chemical library screen, the compound 4-hydroxyacetophenone (4-HAP) was found to target mechanical changes in cell shape important for cell division. 2. When treated with 4-HAP, deformable pancreatic cancer cells became stiffer and exhibited decreased metastatic behavior. Evidence Rating Level: 3 (Average) Study Rundown: Current chemotherapy drugs generally...
Originally published by Harvard Health. What Is It? The pancreas (PAN-cree-us) is an organ that sits in the left side of your belly. The pancreas has two main functions. It makes digestive enzymes (proteins that break down food) and hormones that regulate blood sugar, such as insulin. Pancreatic (PAN-cree-at-ick) occurs when abnormal cells...
1. Long-standing type II diabetes mellitus in patients with pancreatic cancer is associated with decreased survival compared to non-diabetics. 2. No differences in survival were observed in patients with recent onset diabetes (<4 years prior to cancer diagnosis). Evidence Rating Level: 3 (Average) Study Rundown: Pancreatic cancer is the fourth leading cause...