• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Low-intensity pulsed ultrasound decreases major amputation in patients with critical limb ischemia

byDavy LauandAlex Chan
August 23, 2021
in Chronic Disease, Surgery
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. Patients with chronic limb ischemia (CLI) treated with low-intensity pulsed ultrasound (LIPUS) had lower rates of amputation compared to those treated under standard care without LIPUS, after 5-year follow-up.

2. No difference in 5-year rates of survival or major adverse cardiovascular events were found between CLI patients treated with or without LIPUS.

Evidence Rating Level: 2 (Good)

Critical limb ischemia (CLI) is defined as insufficient tissue perfusion for greater than 14 days, and is considered the end-stage of peripheral artery disease (PAD). CLI patients are at greater risk of amputation, cardiovascular issues, and death. In fact, one third or more of CLI patients are not offered a choice when it comes to amputation. When considering the costs, rehabilitation needs, and psychological burden for CLI patients with amputations, less invasive interventions for CLI could vastly improve quality of life. Low-intensity pulsed ultrasound (LIPUS) has been shown to induce microvascular regeneration by stimulating various angiogenic factors, such as IL-8 and vascular endothelial growth factor (VEGF). The current cohort study based in Hiroshima, Japan examined 5-year outcomes for atherosclerotic CLI patients that were and were not treated with LIPUS. The study population consisted of 14 patients in the LIPUS group, enrolled between 2011 and 2015, with 14 historical control patients that were treated under standard guidelines (no LIPUS) between those same years. No significant differences in sample parameters were found between the groups. The average (SD) LIPUS exposure duration was 381 (283) days. The results showed that there were fewer amputations in the LIPUS group, with only 3 major amputations compared to 14 in the control: The amputation-free survival rate was significantly greater in the LIPUS group. However, there were no differences in deaths or mortality-free survival rates, with both groups having 7 deaths. Finally, there were no differences in major adverse cardiovascular events (MACE): the LIPUS group had 2 cardiovascular deaths, 1 patient with stroke, and 1 hospitalized for heart failure, whereas the control group had 3 cardiovascular deaths, 1 patient with stroke, and 2 myocardial infarctions. Overall, LIPUS is associated with a lower risk of amputation in CLI patients, but not with any differences in survival or MACE rates.

Click to read the study in PLOSONE

Image: PD

@2021 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

RELATED REPORTS

Sodium-glucose co-transporter-2 inhibitors may decrease risk of in-stent thrombosis

2 Minute Medicine Rewind February 13, 2023

Surgical bypass for chronic limb-threatening ischemia reduces risk of adverse limb events

Tags: thrombosisvascular surgery
Previous Post

2 Minute Medicine Rewind August 23, 2021

Next Post

Combination of buprenorphine and naloxone may be safe for those hospitalized with acute hepatitis A

RelatedReports

Endocrinology

Sodium-glucose co-transporter-2 inhibitors may decrease risk of in-stent thrombosis

March 24, 2023
Variability in interpretation of breast biopsy slides associated with low verification of atypia and ductal carcinoma in situ
Weekly Rewinds

2 Minute Medicine Rewind February 13, 2023

February 13, 2023
Soaring rates of peripheral artery disease, now over 200 million cases worldwide
Cardiology

Surgical bypass for chronic limb-threatening ischemia reduces risk of adverse limb events

December 28, 2022
Cardiology

Diabetes is a risk factor for high platelet reactivity post percutaneous coronary intervention

December 26, 2022
Next Post
CT texture analysis may predict liver insufficiency after hepatectomy

Combination of buprenorphine and naloxone may be safe for those hospitalized with acute hepatitis A

Nearly Half of All Pediatric Buprenorphine Exposures Result in Hospitalization

Anti-psychotic medication use during pregnancy not associated with attention-deficit/hyperactivity disorder, autism spectrum disorder or small for gestational age in children

Niraparib may lengthen progression-free survival for patients with recurrent ovarian cancer

Younger adults with extremity soft-tissue sarcoma may be more likely to receive chemotherapy and less likely to receive radiation therapy compared to older adults

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Metformin use may decrease risk of osteoarthritis development
  • Intensive blood pressure lowering by non-physician healthcare providers significantly reduces the risk of cardiovascular disease
  • Expectant management of patent ductus arteriosus noninferior to early ibuprofen use
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options