• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home StudyGraphics

#VisualAbstract: Mixed vaccination with ChAdOx1-S followed by BNT162b2 induces a robust humoral immune response

byMinjee Kim
July 29, 2021
in StudyGraphics
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

RELATED REPORTS

BNT162b2 booster is safe and reduces COVID-19 transmission in older adults

The Scan by 2 Minute Medicine®: The Genetics of Alzheimer’s Disease, the Silent Killer, a Holiday Blizzard and an HIV Vaccine on the Horizon

Vaccines for Zaire Ebola virus disease are safe and generate an immune response

  1. Levels of antibodies against the trimeric spike protein and receptor-binding domain were 36- and 77-fold higher in the BNT162b2 group compared to control.
  2. There were no vaccine-related serious adverse events.

Evidence Rating Level: 1 (Excellent) 

Study Rundown: Current research on COVID-19 vaccination has revolved around a homologous dosing schedule (administering the same vaccine sequentially). With supplies becoming scarce globally, the need to interchange COVID-19 vaccines is growing. Until now, limited research has been conducted to assess the effect of a heterologous COVID-19 vaccine schedule in humans. This open-label randomized controlled trial aimed to assess the safety and efficacy of a second dose of BNT162b2 (Pfizer-BioNTech mRNA vaccine) in patients who received a first dose of ChAdOx1-S (AstraZeneca vaccine) approximately 8-12 weeks prior to study enrollment. Primary outcome for this study was immunogenicity to SARS-CoV-2 trimeric spike protein and receptor binding domain (RBD), measured by immunoassay at 14 days after second vaccination. Secondary outcome included neutralizing antibody titers, measured by neutralization assay at two weeks. According to study results, IgG titers against the spike protein and RBD antibodies both increased from baseline to day 14 in the BNT162b2 booster group. There were no serious vaccine-related adverse events. This study was strengthened by a randomized trial that sampled a large group of individuals from multiple hospitals in Spain.

Click to read the study in The Lancet

Relevant Reading: Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

In-depth [randomized controlled trial]: Between Apr 24-30, 2021, 678 patients were assessed for eligibility across five university hospitals in Spain. Included patients were ≥18 years of age who previously received the ChAdOx1-S COVID-19 vaccine 8-12 weeks before screening. Altogether, 676 patients were enrolled and randomized, of which 673 completed the study to day 14 (448 assigned to BNT162b2: 441 in immunogenicity analysis vs. 448 in reactogenicity analysis, and 226 assigned to control: 222 included in immunogenicity analysis). Mean age among enrolled patients was 44 years (standard deviation [SD] 9) and the majority (n=382, 57%) were women.

The primary outcome of IgG antibodies against SARS-CoV-2 spike protein in the intervention group was substantially greater at day 14 (3684.87 BAU/mL, 95% confidence interval [CI] 3429.87-3958.83) than at baseline (98.40 BAU/mL, 95% CI 85.69-112.99). This was also true for mean titers of RBD antibodies (7756.68 BAU/mL, 95% CI 7371.53-8161.96 at day 14 vs. 71.46 BAU/mL, 95% CI 59.84-85.33 at baseline, p<0.0001). The intervention-to-control ratio was 36.41 (95% CI 29.31-45.23) for trimeric spike protein and 77.69 (95% CI 59.57-101.32) for RBD protein. The secondary outcome of neutralizing antibodies was measured in both the intervention (BNT162b2) and control group. Geometric mean titers of neutralizing antibodies were significantly higher in the intervention group (1905.69  , 95% CI 1625.65-2233.98) compared with control (41.81, 95% CI 27.18-64.32, p<0.0001), at day 14 of BNT162b2 vaccine. There were no serious vaccine-related adverse events. Overall, findings from this study suggest that BNT162b2 may serve as an appropriate second dose in patients primed with ChAdOx1-S. 

Tags: #AZD1222#COVID vaccination#Mixed vaccination#Pfizer-BioNTechastrazenecabiontechbnt162b2ChAdOx1-Scovidcovid vaccineCOVID-19 antibodiesHeterologous vaccinationimmunogenicitypfizervaccination
Previous Post

#VisualAbstract Cases of post-COVID-19 diffuse hair shedding may have a delayed presentation and be shorter in duration than typical acute telogen effluvium

Next Post

#VisualAbstract: Induction chemotherapy may improve survival in patients with esophageal adenocarcinoma

RelatedReports

Social networks play key roles in parental vaccination decisions
Infectious Disease

BNT162b2 booster is safe and reduces COVID-19 transmission in older adults

January 30, 2023
The Scan by 2 Minute Medicine®:  Ultra-Trail du Mont-Blanc, Taylor Swift, NBA rookie Chet Holmgren and Magic Mushrooms!
The Scan by 2 Minute Medicine®

The Scan by 2 Minute Medicine®: The Genetics of Alzheimer’s Disease, the Silent Killer, a Holiday Blizzard and an HIV Vaccine on the Horizon

January 11, 2023
2 Minute Medicine Rewind November 23 – November 30, 2014
Emergency

Vaccines for Zaire Ebola virus disease are safe and generate an immune response

January 4, 2023
Novel coronavirus identified from patients with pneumonia in Wuhan, China
Chronic Disease

Long COVID syndrome may be associated with insomnia and excessive sleepiness

November 21, 2022
Next Post
#VisualAbstract: Induction chemotherapy may improve survival in patients with esophageal adenocarcinoma

#VisualAbstract: Induction chemotherapy may improve survival in patients with esophageal adenocarcinoma

Ultrasound enhances gastrointestinal absorption of drugs at low frequencies

7-day antibiotic therapy is noninferior to 14-day therapy in afebrile men with urinary tract infection

Sleep duration inversely related to childhood type 2 diabetes risk makers

Association between BMI and diabetes risk among low-middle income countries varies considerably by geographical region

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Momelotinib reduces symptom burden compared to danazol in patients with myelofibrosis
  • Machine renal perfusion reduces delayed graft function after transplantation
  • COVID-19 mRNA vaccines are safe and effective in children aged 5 to 11 years
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options