Tag: vaccination

1. The ChAdOx1 nCov-19 (AstraZeneca) vaccine was not effective for the prevention of mild-to-moderate COVID-19 infection caused by the B.1.351 variant.  2. The ChAdOx1 nCov-19 vaccine was effective against mild-to-moderate non-variant COVID-19 infection after a single injection. Evidence Rating Level: 1 (Excellent)      Study Rundown: With the emergence of COVID-19 variants, there is the...
1. No significant increase in spontaneous abortion, preterm birth, major structural defects, or small for gestational age rates were found in women receiving 9vHPV vaccine during pregnancy (within 19 weeks pregnant). 2. No significant differences were found in adverse birth outcomes when comparing vaccinations in women 22 weeks before last...
1. The plant-based quadrivalent virus-like particle (QVLP) seasonal influenza vaccine provided strong protection against respiratory illness and influenza-like illness. 2. The QVLP vaccine had a similar safety profile to other current non-living influenza vaccines, with the vast majority of adverse events being mild to moderate. Evidence Rating Level: 1 (Excellent) Study Rundown:...
1. With 70% vaccination coverage, a 3rd trimester maternal vaccine for respiratory syncytial virus (RSV) was modelled to reduce RSV infection rates by 16.6% in infants younger than 3 months.  2. Incidence rate of RSV infections in the first 6 months of life for infants born to unvaccinated mothers was...
Advance care planning in patients with advanced cancer: A 6-country, cluster-randomised clinical trial 1. An advanced care planning (ACP) intervention was not found to increase quality of life compared to usual care, in patients with advanced lung or colorectal cancer. 2. ACP was found to increase the number of patients receiving...
1. Postmarketing surveillance programs of Food and Drug Administration approved vaccines were the most common source of safety data triggering safety label changes. 2. The most common safety label changes included changes in population restrictions and allergies. Evidence Rating Level: 3 (Average) Study Rundown: Food and Drug Administration (FDA) approved vaccines undergo...
1. In this retrospective populated-based cohort study, the annual inactivated influenza intramuscular vaccination was associated with a small absolute increase in subdeltoid bursitis. 2. When compared to nurses, vaccination by medical assistants may be associated with increased risk of vaccination attributable bursitis. Evidence Rating Level: 2 (Good) Study Rundown: Vaccination induced bursitis...
1. The full two-dose influenza vaccination series was significantly more effective in preventing future influenza compared to partial vaccination. Evidence Rating Level: 2 (Good) Childhood influenza is a significant health burden, with vaccination being the primary strategy to prevent transmission. Guidelines suggest a primer dose followed by a booster for patients receiving...
Association of Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers With Testing Positive for Coronavirus Disease 2019 (COVID-19) 1. No association was found between angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker use and test-positivity for COVID-19. Evidence Rating Level: 2 (Good) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the...
1. High-density microarray patches (HD-MAPs) for influenza vaccination were well-tolerated and resulted in similar or improved immune response at one-sixth the standard dose compared to intramuscular injection of commercial quadrivalent influenza vaccine. Evidence Rating Level: 2 (Good) Microarray patches (MAPs) are advantageous compared to needle injection of vaccination due to greater acceptability,...