Tag: vaccination

Individuals not immune to COVID-19 had at least a 45% decreased risk of COVID-19 infection if at least one family member was immune (through previous infection or two vaccine doses). Evidence Rating Level: 2 (Good) Study Rundown: SARS-CoV-2 is predominantly transmitted through person-to-person contact, rendering the spread of this virus through...
1. Approximately 8.5 million children were estimated to have missed DTP3 and MCV1 vaccinations in 2020 due to the global pandemic. 2. The largest disruptions were seen in April and May 2020, with some countries recovering to annual targets by the end of 2020. Evidence Rating Level: 3 (Average) Study Rundown: The...
Levels of antibodies against the trimeric spike protein and receptor-binding domain were 36- and 77-fold higher in the BNT162b2 group compared to control. There were no vaccine-related serious adverse events. Evidence Rating Level: 1 (Excellent)  Study Rundown: Current research on COVID-19 vaccination has revolved around a homologous dosing schedule (administering the...
 1. Doses of recommended non-influenza vaccines administered to children of all age groups decreased significantly in Southern California following the stay-at-home order at the beginning of the COVID-19 pandemic. 2. During the recovery phase of the pandemic, weekly vaccination rates recovered quickly in children younger than 24 months, but remained significantly...
1. Over a mean follow-up period of 3.6 years, no significant association was detected between maternal influenza vaccination during pregnancy and early childhood health outcomes including pediatric asthma, neoplasms and sensory impairment. Evidence Rating: 2 (Good) Study Rundown: Vaccine hesitancy, particularly during pregnancy and early childhood, is a key issue that...
1. The initial doses of the Pfizer and AstraZeneca vaccines were 91% and 88% efficacious in reducing COVID-19 hospitalizations one month after vaccination. 2. Combined vaccine efficacy of the Pfizer and AstraZeneca in preventing hospital admission due to COVID-19 among those aged 80 years and older was approximately 83%. Evidence Rating...
1. The ChAdOx1 nCov-19 (AstraZeneca) vaccine was not effective for the prevention of mild-to-moderate COVID-19 infection caused by the B.1.351 variant.  2. The ChAdOx1 nCov-19 vaccine was effective against mild-to-moderate non-variant COVID-19 infection after a single injection. Evidence Rating Level: 1 (Excellent)      Study Rundown: With the emergence of COVID-19 variants, there is the...
1. No significant increase in spontaneous abortion, preterm birth, major structural defects, or small for gestational age rates were found in women receiving 9vHPV vaccine during pregnancy (within 19 weeks pregnant). 2. No significant differences were found in adverse birth outcomes when comparing vaccinations in women 22 weeks before last...
1. The plant-based quadrivalent virus-like particle (QVLP) seasonal influenza vaccine provided strong protection against respiratory illness and influenza-like illness. 2. The QVLP vaccine had a similar safety profile to other current non-living influenza vaccines, with the vast majority of adverse events being mild to moderate. Evidence Rating Level: 1 (Excellent) Study Rundown:...
1. With 70% vaccination coverage, a 3rd trimester maternal vaccine for respiratory syncytial virus (RSV) was modelled to reduce RSV infection rates by 16.6% in infants younger than 3 months.  2. Incidence rate of RSV infections in the first 6 months of life for infants born to unvaccinated mothers was...