• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Multiple treatment trajectories exist in adolescent depression

byShayna BejaimalandAnees Daud
December 5, 2017
in Chronic Disease, Emergency, Pediatrics, Psychiatry, Public Health
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

1. In this longitudinal retrospective cohort study, there were multiple treatment trajectories identified among youth with depression.

2. Psychotherapy monotherapy was associated with the lowest incidence of hospitalization for depression and attempted suicide rates whereas patients on dual antidepressant and psychotherapy had the highest incidence of hospitalization and attempted suicide.

Evidence Rating Level: 2 (Good)

Study Rundown: Depression is common in childhood and adolescence and trajectories during and after pharmacologic and non-pharmacologic therapies vary across individuals. Many existing studies on the treatment in depressed youth are cross-sectional in nature and do not characterize individual trajectories which is likely heterogeneous. This longitudinal cohort study aimed to characterize heterogeneity in 12-month trajectories of psychotherapy and antidepressant treatment in youths with depression.

Eight classes of patients each with similar treatment trajectories in the year following diagnosis were identified. Youth receiving psychotherapy monotherapy had the lowest incidence of inpatient hospitalization for depression or attempted suicide; youth receiving dual antidepressant and psychotherapy had the highest incidence of attempted suicide during the assessment and post-assessment period. Strengths of this study included assessment of trajectories after depression treatment in a large research claims database. Limitations of this study included the use of only privately insured patients with treatment-seeking behaviour and thus may not be generalizable to higher-risk populations.

Click to read the study, published in JAMA Pediatrics

Relevant Reading: Suicidality and aggression during antidepressant treatment: systematic review and meta-analyses based on clinical study reports

RELATED REPORTS

Wellness Check: Mental Health

Exercise improves symptoms in adults with depression

Wellness Check: Exercise

In-Depth [retrospective cohort]: This retrospective longitudinal cohort study used data from the MarketScan Commercial Claims research database from 2007 to 2014 to identify youth younger than 18 years old without baseline bipolar disorder who were insured for 12 months prior to and at least 12 months after a qualifying diagnosis of depression. Follow-up was complete until the end of insurance coverage or December 31, 2014. The index diagnosis was defined as a single inpatient admission or 2 outpatient claims where the patient received a diagnosis of depression using International Classification of Disease, 9th Revision coding. Observation time was divided into three periods: 12 months prior to index diagnosis (baseline period) for gathering baseline characteristics, 12 months following index diagnosis of depression (assessment period) to determine treatment trajectories, and the period from the end of the assessment period through end of follow-up (post-assessment period). Main outcomes were psychotherapy and antidepressant use classified by latent class analysis and incident rates of inpatient hospitalization and attempted suicide. Latent class and univariate analyses were used for statistical analysis.

Overall, 8 district trajectories were identified of 84,909 youth: no treatment (1 class, n = 10 599; 13%), antidepressant monotherapy (2 classes, n = 15 287; 18%), psychotherapy monotherapy (2 classes, n = 40 313; 48%), dual therapy (3 classes, n = 18 710; 22%). The overall incidence of attempted suicide and inpatient hospitalization declined from assessment period to the post-assessment period. Psychotherapy monotherapy had the lowest incidence of attempted suicide (0.8 per 100 person-years) and inpatient hospitalization (3.5 per 100 person-years) during the assessment period and post assessment period (0.5 per 100 person-years and 1.3 per 100 person-years, respectively). The group receiving dual therapy had the highest incidence of attempted suicide during the assessment period (4.7-7.1 per 100 person-years depending on class) and post-assessment period (1.5-1.7 per 100 person-years).

Image: CC/Flickr

©2017 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: adolescent healthdepression
Previous Post

Parents report greater optimism than oncologists about their child’s cancer prognosis

Next Post

Clinician denial of certain patient requests linked with decreased satisfaction

RelatedReports

Quick Take: Prevalence and Treatment of Depression, Anxiety, and Conduct Problems in US Children
Wellness

Wellness Check: Mental Health

March 30, 2023
Parents often unaware of adolescents’ suicidal thoughts
Lifestyle

Exercise improves symptoms in adults with depression

March 13, 2023
Adolescents’ muscle strength associated with lower cardiometabolic risk
Wellness

Wellness Check: Exercise

March 9, 2023
Association of Use of Oral Contraceptives With Depressive Symptoms Among Adolescents and Young Women
Pediatrics

Youth depression and anxiety rates increased during the COVID-19 pandemic

February 17, 2023
Next Post
Use of plant-based therapies and menopausal symptoms

Clinician denial of certain patient requests linked with decreased satisfaction

2 Minute Medicine Rewind December 4, 2017

Brain lesions on MRI linked with subsequent increased stroke risk

Brodmann area 25 may have role in causing peri-ictal systolic hypotension in patients with epilepsy

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Addition of fludrocortisone to hydrocortisone is beneficial in management of septic shock
  • Surveillance testing of staff at nursing facilities reduces resident COVID-19 mortality
  • Childhood maltreatment may cause mental health problems
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options