• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Patients with psoriasis at an increased risk of avascular necrosis

byRishi ChopraandDavid Wang
December 26, 2016
in Chronic Disease
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

1. In a population-based cohort study of over 28 000 patients with psoriasis and their age- and sex-matched controls, patients with psoriasis was associated with an increased risk of avascular necrosis (AVN).

2. In patients with psoriasis, AVN risk was positively associated with male sex, age younger than 30 years, corticosteroid use, severe psoriasis, and psoriatic arthritis.

Evidence Rating Level: 3 (Average)       

Study Rundown: Psoriasis is a chronic, inflammatory skin disease mediated by pro-inflammatory cytokines. Although many chronic inflammatory disorders are associated with increased risk of AVN. there is a paucity of evidence that links psoriasis and AVN. Given the similar mechanisms proposed for pathogenesis and the shared comorbidities between these disorders, the purpose of this study was to assess the risk of AVN in a cohort of patients with psoriasis.

The study retrospectively investigated the incidence of AVN in a population-based cohort of over 28 000 patients with psoriasis and over 110 000 age- and sex-matched controls. At the conclusion of the study, psoriasis was associated with an increased risk of AVN. The results of this study demonstrate that psoriatic patients with localized pain in a weight bearing joint may require further evaluation for AVN, especially with a history of corticosteroid use. This study is strengthened by the use of a large, nationally representative, population-based cohort that was matched with respect to age, sex, and medical history of diabetes mellitus, hip fracture, and alcohol dependence. However, this study was limited by the lack of matching of patients and controls for hyperlipidemia, kidney transplantation, hypertension, cardiovascular disease, obesity, chronic kidney disease, medication use (including bisphosphonates and corticosteroids), as well as other confounders which were not documented in the database. Multi-center prospective trials that control for these AVN risk factors may improve the validity of the study.

Click to read the study in JAAD

Relevant Reading: Incidence of osteonecrosis associated with corticosteroid therapy among different underlying diseases: prospective MRI study

RELATED REPORTS

#VisualAbstract: IL-17 inhibitors are associated with higher treatment persistence than TNF inhibitors in patients with psoriasis and psoriatic arthritis

#VisualAbstract: Both dermatologists and patients with psoriatic disease expressed positive perspectives on strategies to improve cardiovascular disease prevention

#VisualAbstract Psoriasis is associated with an increase in incident venous thromboembolism and peripheral vascular disease

In-Depth [retrospective cohort]: This study retrospectively evaluated the association between psoriasis and AVN via a population-based cohort of Taiwanese patients selected from a National Health Insurance Research Database. Overall, this study identified 28 268 patients with psoriasis and 113 072 controls without psoriasis matched for age, sex, and medical history of diabetes mellitus, hip fracture, and alcohol dependence. Stratified Cox regression models were utilized to calculate the risk of developing AVN. Multivariate analyses were adjusted for medical history, medication use, and topical and systemic corticosteroids use. The risk of AVN was higher in patients with psoriasis (adjusted HR: 1.96; 95%CI 1.62-2.38). The risk for developing AVN among patients with psoriasis was significantly higher in men, in those with severe and mild psoriasis, in those with and without psoriatic arthritis (PsA), and in those who did and did not use oral or parenteral steroids. Among patients with psoriasis, the risk for AVN was higher for men (HR: 2.20; 95%CI 1.77-2.72) than for women (HR: 1.30; 95%CI 0.84-1.99), for patients with severe psoriasis (HR: 3.21; 95%CI 2.09-4.92) than for those with mild psoriasis (HR 1.75; 95%CI 1.42-2.17), for patients with PsA (HR: 4.34; 95%CI 1.80-10.45) than for those without PsA (HR 1.88; 95%CI 1.55-2.29), and for patients who used oral or parenteral steroids (HR 4.92; 95%CI 1.49-16.25) than for those who used systemic corticosteroids (HR 1.94; 95%CI 1.59-2.37).

Image: CC/Wiki/Jfrolick

©2016 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: avascular necrosispsoriasis
Previous Post

Increased mortality in mothers after the birth of an infant with major congenital anomalies

Next Post

2 Minute Medicine Rewind December 25, 2016

RelatedReports

#VisualAbstract: IL-17 inhibitors are associated with higher treatment persistence than TNF inhibitors in patients with psoriasis and psoriatic arthritis
StudyGraphics

#VisualAbstract: IL-17 inhibitors are associated with higher treatment persistence than TNF inhibitors in patients with psoriasis and psoriatic arthritis

April 7, 2022
#VisualAbstract: Both dermatologists and patients with psoriatic disease expressed positive perspectives on strategies to improve cardiovascular disease prevention
StudyGraphics

#VisualAbstract: Both dermatologists and patients with psoriatic disease expressed positive perspectives on strategies to improve cardiovascular disease prevention

January 28, 2022
#VisualAbstract Psoriasis is associated with an increase in incident venous thromboembolism and peripheral vascular disease
StudyGraphics

#VisualAbstract Psoriasis is associated with an increase in incident venous thromboembolism and peripheral vascular disease

December 16, 2021
#VisualAbstract Risk of serious infection in patients with moderate to severe psoriasis is associated with the type of biologic treatment
StudyGraphics

#VisualAbstract Risk of serious infection in patients with moderate to severe psoriasis is associated with the type of biologic treatment

August 13, 2021
Next Post
Cardiac biomarkers unnecessarily ordered in emergency departments

2 Minute Medicine Rewind December 25, 2016

Disparities exist in economic impact of childhood food allergy

AAP supports further development of quality measures

Stochastic resonance stimulation may decrease apnea of prematurity

Resuscitation of extremely premature infants with room air may increase mortality

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

Get 2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Wellness Check: Mental Health
  • #VisualAbstract: Addition of elotuzumab to lenalidomide and dexamethasone did not significantly improve survival outcomes in newly diagnosed, transplant-ineligible multiple myeloma
  • #VisualAbstract: Pretreatment with radiotherapy and two cycles of concurrent cisplatin may reduce toxicity in locally advanced nasopharyngeal carcinoma
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.