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EvidencePulse™ by 2 Minute Medicine 2026 evidence scan 3 reports You asked top stroke trials 2026 Synthesizing medical evidence... Top 2026 stroke trial results: OCEANIC — ischemic stroke: 6.2% vs 8.4% OPTION* — mRS 0–1: 43.6% vs 34.2% ORIENTAL* — mRS 0–2: 58.6% vs 46.6% *Higher sICH in intervention arms Participants randomizedN OCEANIC 12,327 OPTION 570 ORIENTAL 564 Ask about guidelines or landmark trials... ↑ Try EvidencePulse™ Ask the evidence.
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Home All Specialties Chronic Disease

Positive psychotherapy may be similarly effective to traditional cognitive behavioural therapy for panic disorder

byPaary BalakumarandSimon Pan
August 21, 2026
in Chronic Disease, Imaging and Intervention, Psychiatry
Reading Time: 2 mins read
Quick Take: Prevalence and Treatment of Depression, Anxiety, and Conduct Problems in US Children
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1. Positive Psychotherapy (PPT) produced anxiety and well-being outcomes statistically comparable to standard CBT, suggesting it may be a viable alternative for patients who do not respond to or prefer not to pursue traditional exposure-based treatment.

2. Both interventions demonstrated durable, clinically meaningful improvement sustained at three-month follow-up in an online group format

Evidence Rating Level: 1 (Excellent) 

This randomized controlled trial compared Positive Psychotherapy (PPT) to standard Cognitive Behavioral Therapy (CBT) for anxiety disorders delivered in an online group format, addressing the need for alternative, patient-tailored treatment options. Investigators randomized 110 adults with panic disorder, generalized anxiety disorder, or social anxiety disorder (per ICD-10 criteria) to ten weeks of manualized group therapy (PPT n=53; CBT n=57), with outcomes assessed at baseline, post-treatment, and three-month follow-up using validated measures of anxiety (BAI, PAS, GAD-7, FQ), subjective happiness/quality of life (PPTI, FS, SWLS), and psychological distress (ISR, PHQ-9). Linear mixed models revealed no significant group × time interactions across any outcome, indicating that improvement trajectories did not differ between treatments. Both groups showed statistically significant, medium-to-large effect size improvements in anxiety and distress from pre- to post-treatment, with gains maintained at three-month follow-up. The only significant between-group difference was on the Fear Questionnaire, favoring CBT, though this did not translate to differential change over time. Limitations included a predominantly female sample (97.3%), multiple treating therapists, and 18–21% attrition.

Click here to read this study in PLOS One

Image: PD

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Tags: cognitive behavioral therapyPanic Disorderpsychiatrypsychotherapy
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EvidencePulse™ by 2 Minute Medicine 2026 evidence scan 3 reports You asked top stroke trials 2026 Synthesizing medical evidence... Top 2026 stroke trial results: OCEANIC — ischemic stroke: 6.2% vs 8.4% OPTION* — mRS 0–1: 43.6% vs 34.2% ORIENTAL* — mRS 0–2: 58.6% vs 46.6% *Higher sICH in intervention arms Participants randomizedN OCEANIC 12,327 OPTION 570 ORIENTAL 564 Ask about guidelines or landmark trials... ↑ Try EvidencePulse™ Ask the evidence.
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