• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Gastroenterology

Preoperative coagulation status may predict liver transplant complications

byRehan SaiyedandChaz Carrier
January 23, 2015
in Gastroenterology, Surgery
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

1. Low pre-operative fibrinogen and protein C levels were independently associated with the postoperative incidence of hemorrhage and thrombosis, respectively, following living donor liver transplantation.

2. Out of 403 consecutive patients undergoing living donor liver transplants, 9% experienced hemorrhagic complications and 5% had thrombotic complications.

Evidence Rating Level: 2 (Good)

Study Rundown: The liver plays a significant role in the production of hemostatic factors, including both activators and inhibitors of clot formation. Consequently, disruption in liver function is often accompanied by a concomitant disruption of coagulation processes. In the setting of liver failure, compensatory processes such as upregulation of von Willebrand factor attempt to preserve the coagulation state.  When a patient receives a living donor liver transplantation (LDLT), the hemostatic balancing is once again disrupted by the improved function of the liver graft. With the relatively high prevalence of complications such as hemorrhage and thrombosis following LDLT, the authors sought to characterize the hemostatic status of the transplant recipient pre-operatively and identify any potentially predisposing factors to hemorrhagic or thrombotic complications. Researchers found that lower levels of fibrinogen (pro-clotting) and protein C (anti-coagulant) were independently predictive of post transplant hemorrhagic and thrombotic complications, respectively. Such findings are likely reflective of the imbalance in pro and anti coagulants from liver dysfunction that persists into the post-transplantation phase. Limitations of the study included its retrospective nature, the relatively low prevalence of both complications, and the lack of incorporation of the post-transplant hemostatic status and administered transfusions and antithrombotic medications into the analysis.

Click to read the study in Liver Transplantation

Relevant Reading: Hypercoagulability as a contributor to thrombotic complications in the liver transplant recipient

RELATED REPORTS

AAV gene therapy shows durable benefit in hemophilia B

Hereditary erythrocytosis is associated with a fetal-like EPO isoform

Reduced-dose apixaban noninferior to full dose for cancer-associated thrombosis

In-Depth [retrospective cohort]:  A total of 403 consecutive patients who underwent LDLT were included in the study. Preoperatively reviewed pro-coagulant lab values included international normalized ratio (INR), and fibrinogen. The analyzed anticoagulants were protein C, protein S, and antithrombin. Hemorrhagic and thrombotic complications were noted within the first 10 days after surgery, and multivariate logistic regression analysis was subsequently performed to account for potentially confounding risk factors. Thirty five (9%) patients had hemorrhagic complications and 21 (5%) had thrombotic complications after LDLT. Patients with hemorrhagic complications had a significantly (p<0.05) lower fibrinogen and antithrombin values, longer cold ischemia time, and more blood loss. However, only a lower fibrinogen value was predictive after multivariate analysis (p<0.0001). Patients suffering thrombotic complications had significantly (p <0.05) lower fibrinogen and protein C values, longer operative time, and more blood loss. Low protein C values were the only independent predictor of thrombotic complications (p<0.0001). By ROC curve analysis, the cutoff value of protein C as a predictor of thrombotic complications was determined to be <25, with a sensitivity and specificity of 0.9 and 0.8, respectively.

More from this author: Hamstring tendons often regenerate after harvest for ACL repair, Pediatric cardiac surgery occurring at earlier age, with better outcomes over 50+ year review, CT texture analysis may predict liver insufficiency after hepatectomy

Image: PD

©2014 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. No article should be construed as medical advice and is not intended as such by the authors, editors, staff or by 2 Minute Medicine, Inc.

Tags: hematologyliver transplanttransplant surgery
Previous Post

Deaths of extremely premature infants decrease, necrotizing enterocolitis deaths on the rise

Next Post

Diffusion tensor imaging may aid in Parkinson’s diagnosis

RelatedReports

Primary thromboembolism prophylaxis may be effective in advanced cancer
Hematology

AAV gene therapy shows durable benefit in hemophilia B

July 7, 2025
New genetic link in pulmonary arterial hypertension holds therapeutic promise
Chronic Disease

Hereditary erythrocytosis is associated with a fetal-like EPO isoform

June 2, 2025
Thrombophilia-associated stillbirth risk appears limited to factor V Leiden
Hematology

Reduced-dose apixaban noninferior to full dose for cancer-associated thrombosis

May 20, 2025
Quick Take: Hospital volume and outcomes for acute pulmonary embolism
Cardiology

Analysis of clinical outcomes utilizing ultrasound-assisted catheter-directed thrombolysis for pulmonary embolism

April 30, 2025
Next Post
Diffusion tensor imaging may aid in Parkinson’s diagnosis

Diffusion tensor imaging may aid in Parkinson’s diagnosis

Adjuvant radiation decreases local recurrence in low-risk breast cancer

Adjuvant radiation decreases local recurrence in low-risk breast cancer

Severe maternal childhood abuse associated with autism in offspring

Video therapy may improve behavioral outcomes in infants at risk for autism

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • 2 Minute Medicine Rewind July 7, 2025
  • Fecal calprotectin is a useful marker for defining small bowel endoscopic remission in Crohn’s disease
  • Body mass index-specific waist circumference thresholds may improve mortality risk stratification in women
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.