• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Preventing RSV in pre-term infants reduces recurrent wheezing

bys25qthea
May 8, 2013
in Chronic Disease, Pediatrics, Public Health, Pulmonology
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

Image: PD. RSV.

1. Prophylaxis with an anti-respiratory syncytial virus (RSV) monoclonal antibody significantly reduced wheezing and recurrent wheezing among preterm infants. 

2. The reduction in wheezing occurred regardless of family history of atopy. 

Evidence Rating Level: 1 (Excellent) 

Study Rundown: The MAKI trial found that prophylaxis of pre-term infants with the anti-RSV monoclonal antibody palivizumab significantly reduced wheezing and recurrent wheeze.  The authors intended to probe what appears to be a causal relationship between RSV infection and recurrent wheeze – not to identify an effective treatment.  The randomization and utilization of a virus-specific drug in this appropriately powered trial provides convincing evidence for a special role for RSV in the development of recurrent wheeze.  Additionally the study showed that preventing RSV infection reduced wheezing regardless of family history of atopy.  The integration of family history in the analysis further strengthens the authors’ argument for a causal role of RSV in recurrent wheeze.  However, the study lacked sufficient time and power to address the issue of asthma.  Also it did not include term infants; therefore the results may not be generalizable to the general population.

Click to read the study, published today in NEJM

RELATED REPORTS

Shionogi and UBE: Novel Antiviral Drug Demonstrates Efficacy in RSV Patients

Ziresovir reduces the severity of respiratory syncytial virus in hospitalized infants

#VisualAbstract: Ziresovir Reduces Signs and Symptoms in Hospitalized Infants with Respiratory Syncytial Virus Infection

Relevant Reading: Evidence for a causal relationship between respiratory syncytial virus infection and asthma

In-Depth [double blind randomized controlled trial]: The study investigated the relationship between RSV infection and recurrent wheeze.  Preterm infants were randomly assigned to receive treatment with the anti-RSV monoclonal antibody palivizumab or placebo during RSV season. The primary outcome was number of parent-reported wheezing days during the first year of life.  Additional outcomes included number of hospitalizations for laboratory-proven RSV infection, and prevalence of recurrent wheeze.  The results showed a 61% relative reduction in number of days with parent-reported wheeze in children who received palivizumab when compared to those who received placebo (95% CI 56-65).  Additionally infants treated with palivizumab had a lower incidence of RSV-related hospitalization (0.9% vs. 5.1% P=0.01) and lower recurrent wheeze (11.2% vs. 20.9% P=0.005) than those treated with placebo.

By Akira Shishido and Mitalee Patil

More from this author: Hospital Acquired MRSA pays no attention to vancomycin effectiveness, Oseltamivir treats avian flu early, Linezolid treats Chronic Extensively Drug-Resistant TB but has a high incidence of adverse effects, Intermittent and continuous antiretroviral therapies are equivalent in the treatment of acute HIV-1 infection, Peginesatide is noninferior to epoetin for anemia in hemodialysis patients [EMERALD Trials], Antibiotics improve outcomes in severe acute malnutrition, Carbapenem resistance in Enterobacteriaceae nearly quadrupled in the last decade, new study finds.

© 2013 2minutemedicine.com. All rights reserved. No works may be reproduced without written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No post should be construed as medical advice and is not intended as such by the authors or by 2minutemedicine.com. PLEASE SEE A HEALTHCARE PROVIDER IN YOUR AREA IF YOU SEEK MEDICAL ADVICE OF ANY SORT. Content is produced in accordance with fair use copyrights solely and strictly for the purpose of teaching, news and criticism. No benefit, monetary or otherwise, is realized by any participants or the owner of this domain.

Tags: MAKIpreterm infantsRSVwheezewheezing
Previous Post

New leukemia mutation offers therapeutic targets

Next Post

Prophylactic platelet transfusions prevent bleeding in hematologic cancers

RelatedReports

RSV positivity associated with reduced serious bacterial infection risk [Classics Series]
Pharma

Shionogi and UBE: Novel Antiviral Drug Demonstrates Efficacy in RSV Patients

February 24, 2025
Clinical practice guidelines linked to improved bronchiolitis outcomes
Infectious Disease

Ziresovir reduces the severity of respiratory syncytial virus in hospitalized infants

October 11, 2024
#VisualAbstract: Ziresovir Reduces Signs and Symptoms in Hospitalized Infants with Respiratory Syncytial Virus Infection
StudyGraphics

#VisualAbstract: Ziresovir Reduces Signs and Symptoms in Hospitalized Infants with Respiratory Syncytial Virus Infection

October 7, 2024
#VisualAbstract: Nirsevimab Reduces Hospitalization for RSV Bronchiolitis
StudyGraphics

#VisualAbstract: Nirsevimab Reduces Hospitalization for RSV Bronchiolitis

July 22, 2024
Next Post
Prophylactic platelet transfusions prevent bleeding in hematologic cancers

Prophylactic platelet transfusions prevent bleeding in hematologic cancers

No long-term follow-up for benign thyroid nodules

No long-term follow-up for benign thyroid nodules

Sleeve gastrectomy surgery linked to more weight loss than lap-band

Sleeve gastrectomy surgery linked to more weight loss than lap-band

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Time-restricted eating does not confer changes in sleep, mood, or quality of life
  • Commonly cited medication triggers may not increase risk of microscopic colitis among older adults
  • Ablation may reduce stroke risk, death, heart failure hospitalization in patients with atrial fibrillation
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.