• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Oncology

Quick Take: Accelerated hypofractionated radiation therapy for elderly frail bladder cancer patients unfit for surgery or chemotherapy

byAliya Ramjaun
January 31, 2019
in Oncology, Surgery, Urology
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

The standard of care for T2-T4aN0M0 muscle-invasive bladder cancer (MIBC) and high-risk non-MIBC in fit patients is radical cystectomy (RC). In patients unfit for RC, or in cases where bladder preservation is desired, trimodality therapy (TMT) incorporating maximal transurethral resection of bladder tumor (TURBT) and radiation therapy (RT) with concurrent chemotherapy (CMT) can be considered, with comparable efficacy in terms of overall cancer-specific and disease-free survival. As many elderly patients are not considered suitable surgical candidates, TMT is often considered in this patient population. However, these patients may also be unfit for chemo-radiation. Hypofractionation has been investigated as a strategy to increase the efficacy of radiation therapy in this patient population. The purpose of this cohort study was to assess the treatment outcomes of definitive image-guided accelerated hypofractionated radiation therapy in 17 elderly patients with MIBC not considered suitable candidates for surgery or TMT. All patients underwent TURBT, however, in 64.7% of patients this was concluded as incomplete due to deep tumor involvement of the bladder wall or wide area of spread. The median overall treatment time was 20 days, with no patients receiving neoadjuvant chemotherapy. Researchers found that complete local response at 3-month cystoscopy was 69%, where 6 patients (35%) developed a local recurrence, and 2 patients (11.7%) developed distant metastases. Overall survival at 1 year and 2 years were 85% and 63%, respectively. This study therefore shows that accelerated hypofractionated radiotherapy alone may provide good control in elderly patients unfit for combination chemotherapy and radiation.

 Click to read the study in the American Journal of Clinical Oncology

Image: PD

©2019 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

RELATED REPORTS

Radiotherapy with cetuximab or durvalumab for advanced HNSCC

Machine learning algorithm shows limited capacity for reducing health spending for radiation therapy outpatients

Systemic Therapy and Stereotactic Body Radiotherapy in Oligoprogressive Breast Cancer or Lung Cancer

Tags: bladder cancerRadiation Therapy
Previous Post

Web-based decision aid fails to improve communication between clinicians and surrogates for patients with prolonged mechanical ventilation

Next Post

#VisualAbstract: Single-Dose Tafenoquine to Prevent Relapse of Plasmodium vivax Malaria

RelatedReports

Patient Basics: Parathyroid Cancer
Chronic Disease

Radiotherapy with cetuximab or durvalumab for advanced HNSCC

November 18, 2024
Parental debt influences child socioemotional well-being
2 Minute Medicine

Machine learning algorithm shows limited capacity for reducing health spending for radiation therapy outpatients

November 25, 2024
Patient Basics: Radiation Therapy
Oncology

Systemic Therapy and Stereotactic Body Radiotherapy in Oligoprogressive Breast Cancer or Lung Cancer

January 8, 2024
Niraparib may lengthen progression-free survival for patients with recurrent ovarian cancer
Oncology

Younger adults with extremity soft-tissue sarcoma may be more likely to receive chemotherapy and less likely to receive radiation therapy compared to older adults

August 23, 2021
Next Post
#VisualAbstract: Single-Dose Tafenoquine to Prevent Relapse of Plasmodium vivax Malaria

#VisualAbstract: Single-Dose Tafenoquine to Prevent Relapse of Plasmodium vivax Malaria

Intrauterine Zika virus infection associated with significant fetal brain abnormalities

Quick Take: Prior dengue virus infection and risk of Zika: a pediatric cohort in Nicaragua

Transthoracic echocardiography can rule out endocarditis in low-risk bacteremic patients

The OVIVA trial: oral antibiotics noninferior to intravenous antibiotics for bone and joint infections

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Intravaginal conjugated oestrogen does not improve continuation rate of ring pessary use
  • Artificial intelligence based clinical decision systems are safe and effective for diabetes management
  • Epic Launchpad propels generative-AI into everyday hospital routines
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.