• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Quick Take: Glucagon Receptor Antagonist–Stimulated α-Cell Proliferation Is Severely Restricted With Advanced Age

byConstance WuandAliya Ramjaun
May 17, 2019
in Chronic Disease, Endocrinology, Gastroenterology, Preclinical
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

RELATED REPORTS

The Scan by 2 Minute Medicine®: Erythritol and Heart Problems, Maternal Health Trends, the Next Big Thing in Diabetes, and Declining Levels of Sea Ice

The Scan by 2 Minute Medicine®: Black History Month, Mr.Beast, Damar Hamlin and on-field CPR, Ozempic Shortage

Sodium-glucose cotransporter 2 inhibitors may reduce incidence of respiratory events in Type 2 diabetics

Glucagon-containing α-cells are important for regulating glucose homeostasis along with insulin-secreting β-cells. Glucagon receptor antagonists (GRAs) hold potential as antidiabetic therapies, but there is a concern that GRAs may cause α-cells to proliferate. While studies evaluating this have been carried out in rodents, these have been limited to young mice, raising questions surrounding the effect of GRAs in adult mice and adult animals in general. In this controlled study, investigators gave a highly selective GRA (JNJ-46207382) to both young and adult mice in order to examine the effect of GRAs on measured α-cell turnover and proliferation. Investigators found that in young mice, the GRA caused a 2.5 fold greater α-cell proliferation. In adult mice, administration of the GRA also resulted in α-cell proliferation, but this proliferation was 60% less than what was observed in young mice. In both young and adult mice, pancreas mass was unaltered by the GRA studied, and islet histology was also normal. Taken together, the results from this study suggest that administration of GRA causes a greater degree of expansion of α-cells in young mice as compared to older mice. This has implications for potential GRA use in middle-aged or elderly patients who may have minimal α-cell proliferation. This study was limited, however, in that it used a single GRA molecule in a rodent model that may or may not be generalizable to humans. The mice used in this study were also non-diabetic, therefore, the effect of GRAs on diabetic α-cells requires further study.

Click to read the study in Diabetes

Image: PD

©2019 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc

Tags: diabetesGlucagon receptor antagonists (GRA)insulin-secreting β-cellsα-cells
Previous Post

Quick Take: Association of Visual Impairment With Economic Development Among Chinese Schoolchildren

Next Post

Use of aspirin for primary prevention linked to increased risk of intracranial hemorrhage

RelatedReports

The Scan by 2 Minute Medicine®:  Ultra-Trail du Mont-Blanc, Taylor Swift, NBA rookie Chet Holmgren and Magic Mushrooms!
The Scan by 2 Minute Medicine®

The Scan by 2 Minute Medicine®: Erythritol and Heart Problems, Maternal Health Trends, the Next Big Thing in Diabetes, and Declining Levels of Sea Ice

March 7, 2023
The Scan by 2 Minute Medicine®:  Ultra-Trail du Mont-Blanc, Taylor Swift, NBA rookie Chet Holmgren and Magic Mushrooms!
The Scan by 2 Minute Medicine®

The Scan by 2 Minute Medicine®: Black History Month, Mr.Beast, Damar Hamlin and on-field CPR, Ozempic Shortage

March 14, 2023
Prescription of antibiotics for acute respiratory infections increasing
Endocrinology

Sodium-glucose cotransporter 2 inhibitors may reduce incidence of respiratory events in Type 2 diabetics

February 16, 2023
Vitamin deficiency may persist after Omega-loop gastric bypass
Cardiology

Vitamin D effective in preventing the progression of pre-diabetes to diabetes

February 14, 2023
Next Post
Use of aspirin for primary prevention linked to increased risk of intracranial hemorrhage

Use of aspirin for primary prevention linked to increased risk of intracranial hemorrhage

Shared decision-making tool for antidepressants improves patient and physician satisfaction

Quick Take: Efficacy of Adjunctive Infliximab vs Placebo in the Treatment of Adults With Bipolar I/II Depression

#VisualAbstract: Effect of Trans-Nasal Evaporative Intra-arrest Cooling on Functional Neurologic Outcome in Out-of-Hospital Cardiac Arrest

#VisualAbstract: Effect of Trans-Nasal Evaporative Intra-arrest Cooling on Functional Neurologic Outcome in Out-of-Hospital Cardiac Arrest

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Similar perinatal outcomes observed amongst conception via natural and assisted reproductive means
  • Combination doxycycline and azithromycin therapy effective in treating severe scrub typhus
  • Adenoma detection rate is inversely associated with post-colonoscopy colorectal cancer risk
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options