• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Dermatology

Quick Take: Treatment Outcomes of Immune-Related Cutaneous Adverse Events

byDonna LeetandAliya Ramjaun
June 29, 2019
in Dermatology, Oncology
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

RELATED REPORTS

#VisualAbstract: Bimekizumab shows a favourable 2-year safety profile in patients with moderate to severe plaque psoriasis

#VisualAbstract: Cutaneous immune-related adverse events were associated with increased survival in patients treated with immune checkpoint inhibitors

#VisualAbstract An ixazomib-based regimen may be a better-tolerated approach in elderly patients with newly diagnosed multiple myeloma

Immune-checkpoint inhibitors (ICIs) have significantly improved outcomes in a variety of malignancies. Immune-related adverse events, however, are common and may lead to treatment discontinuation and adverse events. Immune-related cutaneous adverse events (ircAEs) are the most frequent and earliest to develop, but there is no evidence-based consensus regarding the management of these events. In this retrospective analysis, 285 patients with 427 ircAEs related to ICIs were studied to assess the efficacy of topical and systemic treatments prescribed by dermatologists. The most common ircAEs were pruritus (32%) and maculopapular rash (28%). Researchers found that ircAE phenotype was not associated with primary cancer diagnosis, but was associated with ICI class (p=0.007), in that maculopapular rash was predominant in patients who received combination therapy. Furthermore, dermatologic interventions such as topical corticosteroids, oral anti-pruritics, and systemic immunomodulators significantly reduced the severity of ircAEs (mean Common Terminology Criteria for Adverse Events grade 1.74 at diagnosis vs. 0.71 at follow-up, p=0.001). The largest improvement was observed in maculopapular rashes (mean grade reduction -1.40). Treatment patterns did not differ significantly between dermatologists (p=0.06). In all seven patients with corticosteroid-refractory ircAEs, targeted biologic immunomodulatory therapies improved symptoms. Several biomarkers were elevated in patients with ircAEs: serum interleukin-6 (IL-6) was elevated in 52% of patients, and mean immunoglobulin E serum levels were greater in higher-grade ircAEs. Additionally, grade 3 or higher ircAEs were associated with increased absolute eosinophils (OR 4.1, 95% CI 1.3 to 13.4) and IL-10 (OR 23.8, 95% CI 2.1 to 262.5). In summary, this study demonstrates that most patients with ircAEs were treated effectively with dermatologic interventions, and provides a basis for further controlled trials aimed at validating the safety and efficacy of these treatments in ircAEs and other immune-related adverse events. Finally, this study identified eosinophils, IL-6, IL-10, and immunoglobulin E as potential actionable therapeutic targets for immune-related skin toxicities.

Click to read the study in JCO

Image: PD

©2019 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: adverse eventsimmune modulatorsImmune-checkpoint inhibitor (ICI)Immune-related cutaneous adverse event (ircAE)interleukin 6 (IL-6)
Previous Post

Quick Take: Safety and Efficacy of the Addition of Lapatinib to Perioperative Chemotherapy for Resectable HER2-Positive Gastroesophageal Adenocarcinoma

Next Post

Quick Take: Comparison of Outcomes After Transcatheter vs Surgical Aortic Valve Replacement Among Patients at Intermediate Operative Risk With a History of Coronary Artery Bypass Graft Surgery

RelatedReports

#VisualAbstract: Bimekizumab shows a favourable 2-year safety profile in patients with moderate to severe plaque psoriasis
StudyGraphics

#VisualAbstract: Bimekizumab shows a favourable 2-year safety profile in patients with moderate to severe plaque psoriasis

May 27, 2022
#VisualAbstract: Cutaneous immune-related adverse events were associated with increased survival in patients treated with immune checkpoint inhibitors
StudyGraphics

#VisualAbstract: Cutaneous immune-related adverse events were associated with increased survival in patients treated with immune checkpoint inhibitors

January 21, 2022
#VisualAbstract An ixazomib-based regimen may be a better-tolerated approach in elderly patients with newly diagnosed multiple myeloma
StudyGraphics

#VisualAbstract An ixazomib-based regimen may be a better-tolerated approach in elderly patients with newly diagnosed multiple myeloma

December 18, 2021
#VisualAbstract Assessing early tumour response and immune-related adverse events when undergoing combination nivolumab and ipilimumab therapy for advanced melanoma
StudyGraphics

#VisualAbstract Assessing early tumour response and immune-related adverse events when undergoing combination nivolumab and ipilimumab therapy for advanced melanoma

November 18, 2021
Next Post
Cognitive outcomes in older adults undergoing cardiovascular procedures unclear

Quick Take: Comparison of Outcomes After Transcatheter vs Surgical Aortic Valve Replacement Among Patients at Intermediate Operative Risk With a History of Coronary Artery Bypass Graft Surgery

AAP reaffirms support for adolescents’ rights to confidential reproductive care

Effective adolescent mental health programs incorporate interpersonal skills, emotional regulation, and drug education

Quick Take: Pexidartinib versus placebo for advanced tenosynovial giant cell tumour (ENLIVEN)

Quick Take: Pexidartinib versus placebo for advanced tenosynovial giant cell tumour (ENLIVEN)

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Vitamin and mineral supplementation associated with minimal to no benefit in the primary preventing of cardiovascular disease and cancer – US Preventative Services Task Force
  • RSVpreF vaccine prevents symptomatic respiratory syncytial virus infection
  • Incidence of Kawasaki disease found to be lower during the COVID-19 pandemic in the United States
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.