• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Separate panels of microRNAs may aid in early detection of pancreatic cancer

bys25qthea
January 23, 2014
in Chronic Disease, Endocrinology, Gastroenterology, Oncology
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

Image: PD 

1. Thirty-eight microRNAs were discovered to be differentially expressed in whole blood between patients with pancreatic cancer and healthy controls.

2. Many microRNAs found to be differentially expressed in patients with pancreatic cancer were associated with known oncogenes and signaling pathways.

Evidence Rating Level: 3 (Average)

Study Rundown:  Pancreatic cancer causes significant mortality in the Western world in part due to the fact that many pancreatic cancers are detected at advanced stages. The high mortality associated with pancreatic cancer could be possibility be prevented with early detection of the disease.  A number of retrospective studies have described microRNAs in the serum or plasma that differ between patients with pancreatic cancer and healthy controls. In this current study, whole blood samples from patients with pancreatic cancer and healthy controls were used to identify microRNAs that can be used for the early diagnosis of pancreatic cancer.  Two diagnostic panels were created from these microRNAs and demonstrated the ability to distinguish between patients with pancreatic cancer and healthy controls. The major strength of this study was in the large numbers of patients and the large microRNA panels that were used for discovery.  However, the study was limited in generalizability as all of the cohorts were from one genetic, ethnic and geographic background. Overall, the study does provide evidence of biomarkers in whole blood that could potentially be used to screen for pancreatic cancer and argues for further research on the applicability of these markers in practice.

Click to read the study, published today in JAMA

Click to read an accompanying editorial, published today in JAMA

RELATED REPORTS

Neoadjuvant chemoradiotherapy demonstrates a long-term survival benefit in pancreatic cancer patients when compared to upfront surgery

Stromal Expression of hemopexin is associated with lymph-node metastasis in pancreatic ductal adenocarcinoma

Stromal Expression of hemopexin is associated with lymph-node metastasis in pancreatic ductal adenocarcinoma

Relevant Reading:  Potential epigenetic biomarkers for the diagnosis and prognosis of pancreatic ductal adenocarcinomas

In-Depth [case-control study]: This study used whole blood samples from 435 patients with suspected pancreatic cancer to find blood biomarkers for the early detection of pancreatic cancer. These were first separated into three randomly determined subcohorts: a discovery cohort, a training cohort and a validation cohort.  The discovery cohort identified 38 unique microRNAs that differed between patients with pancreatic cancer and those that were healthy.  When these were tested in a training cohort, two biomarker panels, index I (miR=145, miR-150, miR-223, miR-636) and index II (miR-26b, miR-34a, miR-122, miR-126, miR-145, miR-150, miR-223, miR-505, miR-636, miR-885.5p) were constructed. By combining the panels with serum CA19-9 with serum CA19-9, for index I AUC increased to 0.83 (95% CI, 0.76-0.90), specificity increased to 0.96 (95% CI, 0.62-0.84) and accuracy increased to 0.92 (95% CI, 0.89-0.95) but sensitivity decreased to 0.74 (95% CI, 0.76-0.90).  For index II with CA19-9, specificity increased to 0.97 (95% CI, 0.94-0.99) and accuracy increased to 0.93 (95% CI, 0.90 – 0.95); however AUC remained 0.91 (95% CI, 0.86 – 0.95) and sensitivity decreased to 0.73 (95% CI, 0.61 – 0.83).

By Camellia Banerjee and Brittany Hasty

More from this author: Increased risk of hospitalization following the release of inmates, Terminology used to describe ductal carcinoma in situ impacts patient preferences, Early onset dementia strongly correlated with alcohol intoxication in men, Perceived futility of treatments in the ICU dependent on key patient factors, Worldwide smoking prevalence decreasing as numbers of smokers increase

© 2012-2014 2minutemedicine.com. All rights reserved. No works may be reproduced without expressed written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No post should be construed as medical advice and is not intended as such by the authors, editors, staff or by 2minutemedicine.com. PLEASE SEE A HEALTHCARE PROVIDER IN YOUR AREA IF YOU SEEK MEDICAL ADVICE OF ANY SORT.  

Tags: micrornapancreatic cancer
Previous Post

Warfarin, antibiotic interactions may not be clinically significant in ambulatory setting

Next Post

Parents define children’s oncology-related palliation and pain relief [Pediatrics Classics Series]

RelatedReports

Rectal indomethacin dose escalation for prevention of pancreatitis after endoscopic retrograde cholangiopancreatography in high-risk patients
Oncology

Neoadjuvant chemoradiotherapy demonstrates a long-term survival benefit in pancreatic cancer patients when compared to upfront surgery

March 27, 2022
Stromal Expression of hemopexin is associated with lymph-node metastasis in pancreatic ductal adenocarcinoma
StudyGraphics

Stromal Expression of hemopexin is associated with lymph-node metastasis in pancreatic ductal adenocarcinoma

July 23, 2020
Gastroenterology

Stromal Expression of hemopexin is associated with lymph-node metastasis in pancreatic ductal adenocarcinoma

July 23, 2020
Modified FOLFIRINOX results in longer disease-free survival in metastatic pancreatic cancer patients compared to gemcitabine
Gastroenterology

Modified FOLFIRINOX results in longer disease-free survival in metastatic pancreatic cancer patients compared to gemcitabine

December 22, 2018
Next Post

Parents define children’s oncology-related palliation and pain relief [Pediatrics Classics Series]

Cardiovascular events in Kawasaki Disease not significantly elevated over controls

Cardiovascular events in Kawasaki Disease not significantly elevated over controls

Lower vulvar cancer-related mortality in African Americans

High volume geriatric trauma facilities provide better geriatric trauma outcomes

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Gout flares associated with a transient increase in subsequent risk of cardiovascular events
  • Litifilimab associated with reduced disease severity in patients with cutaneous lupus erythematosus
  • Shorter time to surgical repair of macula-off retinal detachment may improve final visual acuity
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.