Image: PD
1. Daily soy protein powder consumption for 2 years following radical prostatectomy did not reduce biochemical recurrence of prostate cancer in men at high risk of PSA failure.Â
Evidence Rating Level: 1 (Excellent)Â
Study Rundown: Daily soy supplementation taken as a powder for two years was not shown to reduce the recurrence of prostate cancer following radical prostatectomy as measured by PSA levels at regular intervals. It is thought that Asian countries may have lower instances of prostate cancer due to higher levels of soy in the diet. With the growing popularity of supplements, especially various protein powders, this was an informative study for many men. This trial that ended early shows that soy protein powder is not superior to casein-based powder in preventing recurrence. The potential protective mechanism of action of soy isoflavones still should not be fully ruled out. This study examined the role of soy in secondary and tertiary prevention when cancer had already declared itself, but there still may be a role for soy isoflavones in primary prevention of cancers.
Click to read the study, published today in JAMA
Relevant Reading: Soy consumption and prostate cancer risk in men: a revisit of a meta-analysis
In-Depth [randomized study]: This study included 177 patients from 7 centers who were randomized to taking soy protein powder or a casein protein powder (placebo) from 1997-2010. Participants had undergone radical prostatectomy for clinically localized prostate cancer less than 4 months before randomization and had a postsurgery PSA value of less than 0.07 ng/mL. They also fulfilled 1 or more of the following criteria for high risk: preoperative PSA of greater than 20.0 ng/mL, final Gleason score of 8 or greater, established positive surgical margins (but not apical margins), established extracapsular extension (but not in the bladder neck), seminal vesicle invasion, or micrometastases in any removed pelvic lymph nodes. PSA levels were checked at regular intervals, and the primary end points of this trial were the 2-year rate of biochemical recurrence (0.07 ng/mL or higher) and time to recurrence. A blinded interim analysis was conducted once 45 participants had developed recurrence. The trial was ended early because biochemical recurrence of prostate cancer after radical prostatectomy was not shown to be reduced.
By Mike Hoaglin and Brittany Hasty
More from this author: Gastric bypass surgery reduces cardio-metabolic risk factors, Dual-chamber ICDs fail to offer benefit over single chamber ICDs, Childhood migraine associated with infantile colic
© 2013 2minutemedicine.com. All rights reserved. No works may be reproduced without written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No post should be construed as medical advice and is not intended as such by the authors or by 2minutemedicine.com. PLEASE SEE A HEALTHCARE PROVIDER IN YOUR AREA IF YOU SEEK MEDICAL ADVICE OF ANY SORT. Content is produced in accordance with fair use copyrights solely and strictly for the purpose of teaching, news and criticism. No benefit, monetary or otherwise, is realized by any participants or the owner of this domain.Â