• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Subclinical hyperthyroidism associated with hip and any fracture risk

byJeffrey CohenandPriyanka Vedak
May 26, 2015
in Chronic Disease, Endocrinology
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. Subclinical hyperthyroidism was found to be associated with an increased risk of hip and any fractures in this meta-analysis, but was not associated with spine or nonspine fractures.

2. Subclinical hypothyroidism was not associated with hip, any, spine, or nonspine fracture risk in this meta-analysis.

Evidence Rating Level: 1 (Excellent)

Study Rundown: There is an established association between hyperthyroidism and the risk of osteoporosis and fractures. However, the relationship between subclinical thyroid dysfunction, defined as an abnormal thyroid stimulating hormone (TSH) with a normal free thyroxine (FT4), and fracture risk is less well understood. This study pooled data from 13 prospective studies (70 298 participants) to determine whether subclinical thyroid dysfunction was associated with hip fractures, any fractures, spine fractures, and nonspine fractures. Subclinical hyperthyroidism was found to be associated with hip fracture and overall fracture risk, but not spine or nonspine fracture risk. Subclinical hypothyroidism was not associated with fracture risk in this study.

Strengths of this study include the large sample size, thorough analysis of data from each included study, and the use of individual-level data. The participants in this study were predominantly Caucasian females, which may limit the generalizability of the findings. Another weakness of the study is the fact that all participants’ thyroid status was determined at the outset of the included studies and changes would not have been known. Further studies should be performed to understand the clinical implications of the association between subclinical hyperthyroidism and fracture risk and the potential benefits of treating individuals with subclinical hyperthyroidism.

Click to read the study, published today in JAMA

Relevant Reading: Subclinical thyroid dysfunction and incident hip fracture in older adults.

RELATED REPORTS

Thyroid dysfunction not associated with cognitive decline

#VisualAbstract Granuloma annulare was associated with increased risk of type 2 diabetes, hyperlipidemia, and certain autoimmune conditions

Association of potent topical corticosteroids and the risk of osteoporosis and major osteoporotic fractures

In-Depth [meta-analysis]: This study combined data from 13 prospective studies to perform a meta-analysis to assess the relationship between subclinical thyroid dysfunction and fracture risk in 70 298 participants. Thyroid levels were stratified as euthyroid (TSH 0.45-4.49 mIU/L), subclinical hyperthyroidism (TSH <0.45 with normal FT4 levels), and subclinical hypothyroidism (TSH 4.50-19.99 mIU/L, with normal FT4). The occurance of hip fracture was the primary outcome, while fractures of any location, spine, and nonspine were the secondary outcomes. Subclinical hyperthyroidism was found to be associated with hip fracture risk (HR 1.36, 95%CI 1.13-1.64) and any fracture risk (HR 1.28, 95%CI 1.06-1.53), but not nonspine fractures (HR 1.16, 95%CI 0.95-1.41) or spine fractures (HR 1.52, 95%CI 0.93-2.45). The risk of hip, any, and spine fracture was higher among participants with lower TSH levels. There was no association between subclinical hypothyroidism and fracture risk in this study.

Image: PD

©2015 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: HyperthyroidismHypothyroidismosteoporosis
Previous Post

Soy isoflavone supplement yields no improvement in poorly controlled asthma

Next Post

Heparin bridging may increase bleeding without preventing recurrent thromboembolism

RelatedReports

Chronic Disease

Thyroid dysfunction not associated with cognitive decline

September 10, 2021
#VisualAbstract Granuloma annulare was associated with increased risk of type 2 diabetes, hyperlipidemia, and certain autoimmune conditions
Chronic Disease

#VisualAbstract Granuloma annulare was associated with increased risk of type 2 diabetes, hyperlipidemia, and certain autoimmune conditions

June 18, 2021
Eczema more prevalent among older adults than previously thought
Chronic Disease

Association of potent topical corticosteroids and the risk of osteoporosis and major osteoporotic fractures

January 27, 2021
Bisphosphonate use and risk of atypical femur fractures
Chronic Disease

Bisphosphonate use and risk of atypical femur fractures

August 26, 2020
Next Post
Heparin bridging may increase bleeding without preventing recurrent thromboembolism

Heparin bridging may increase bleeding without preventing recurrent thromboembolism

Blood type correlates with egg reserve in infertile women

Arterial embolization successfully treats bleeding in anticoagulated patients

Midlife diabetes associated with cognitive decline

Antibiotic stewardship program for asymptomatic bacteriuria may be effective

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Higher body mass index may be associated with altered vitamin D levels and metabolism
  • #VisualAbstract: Torsemide does not provide additional decrease in mortality compared to furosemide among patients hospitalized for heart failure
  • Community-based adult vision screening program increases access to eye care
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options