Tag: osteoporosis

1. Delayed subsequent denosumab doses were shown to increase the risk for vertebral fractures compared to on-time injection. 2. There was insufficient evidence to determine if with delayed dosing, fracture risk at other locations would be increased. Evidence Rating Level: 2 (Good) Study Rundown: Denosumab, a monoclonal antibody that inhibits the RANK...

1. In this observational study, patients who received one of three direct oral anticoagulants (DOACs) were significantly less likely to have an osteoporotic hip or vertebral fracture compared to those who received warfarin. 2. No difference in fracture risk was detected between individual DOACs. Evidence Rating Level: 2 (Good) Study Rundown: Osteoporotic...

1. Direct oral anticoagulants, specifically apixaban, were associated with lower risk of fracture in patients with atrial fibrillation compared to warfarin. Evidence Rating Level: 2 (Good) Warfarin is commonly used to prevent cardioembolic events in individuals with atrial fibrillation (AF). The impact of warfarin treatment on bone health is clinically...

Association of Anticoagulant Therapy With Risk of Fracture Among Patients With Atrial Fibrillation 1. Direct oral anticoagulants, specifically apixaban, were associated with lower risk of fracture in patients with atrial fibrillation compared to warfarin. Evidence Rating Level: 2 (Good) Warfarin is commonly used to prevent cardioembolic events in individuals with atrial fibrillation...

1. The cathepsin K inhibitor odanacatib reduced the risk of fracture but was associated with significantly increased risk of cardiovascular events, specifically stroke, in postmenopausal women with osteoporosis compared to placebo. Evidence Rating Level: 1 (Excellent) Odanacatib, a cathepsin K inhibitor, reduces bone resorption without compromising bone formation, with further findings suggesting...

Odanacatib for the Treatment of Postmenopausal Osteoporosis: Results of the LOFT Multicentre, Randomised, Double-Blind, Placebo-Controlled Trial and LOFT Extension Study 1. The cathepsin K inhibitor odanacatib reduced the risk of fracture but was associated with significantly increased risk of cardiovascular events, specifically stroke, in postmenopausal women with osteoporosis compared to...

Effect of Early Surgery vs Physical Therapy on Knee Function Among Patients With Nonobstructive Meniscal Tears: The ESCAPE Randomized Clinical Trial Despite multiple studies indicating that arthroscopic partial meniscectomy (APM) is not more effective than physical therapy (PT), this procedure continues to be performed widely in patients with meniscal tears....

1. In postmenopausal osteoporotic women at high risk for fracture, romosozumab followed by alendronate significantly reduced fracture risk compared to alendronate alone. 2. Although the incidence of adverse events were similar between treatment groups, serious cardiovascular adverse events were observed in more romosozumab treated patients. Evidence Rating Level: 1 (Excellent)  Study Rundown:...

1. While osteoporosis medications may have some benefits in chronic kidney disease patients (CKD), the evidence is unclear with respect to their impact on bone mineral density (BMD) and fracture risk. 2. The safety of osteoporosis medications among CKD patients is not clearly established. Evidence Rating Level: 1 (Excellent) Study Rundown: CKD...

1. Based on a cross-sectional study, children and adolescents who reported using stimulant medications were found to have lower bone mineral density (BMD) as assessed by dual-energy x-ray absorptiometry (DXA) of the spine, total femur, and femoral neck measurements. 2. The association observed was linked to the use of stimulant...