Tag: acute kidney injury

1. Older age, male sex, and pre-existing comorbidities were independent risk factors for developing complications following COVID-19 infection. 2. The most common complications included renal, complex respiratory, systemic, and cardiovascular. Evidence Rating Level: 2 (Good)  Study Rundown: Patients hospitalized with COVID-19 are likely to develop in-hospital complications which may worsen their prognosis....
1. The median number of RRT-free days was 12 days (IQR 0-25) in the delayed strategy and 10 days (IQR 0-24) in the more-delayed strategy. 2. Hazard ratio for mortality at day 60 was 1.65 in the more-delayed strategy. Evidence Rating Level: 1 (Excellent) Study Rundown: Uncertainty exists regarding the duration for...
1. The most common complications associated with COVID-19 with high absolute risk were viral pneumonia, respiratory failure, acute kidney failure, and sepsis. 2. Complications highly associated with COVID-19 with low absolute risk were myocarditis, pneumothorax, and disseminated intravascular coagulation. Evidence Rating Level: 2 (Good) During the COVID-19 pandemic, greater than 50 million individuals...
1. In this retrospective cohort study looking at patients admitted to hospital with acute kidney injury, use of angiotensin-converting enzyme inhibitor or angiotensin receptor blocker within six months was associated with decreased mortality. 2. Angiotensin-converting enzyme inhibitor or angiotensin receptor blocker use was also associated with increased risk of hospitalization...
1. Amongst patients undergoing angiography, neither sodium bicarbonate nor acetylcysteine were effective in preventing a composite outcome of death, need for dialysis, or persistent kidney injury. 2. The treatments were also ineffective in reducing risk of contrast-associated acute kidney injury. Evidence Rating Level: 1 (Excellent) Study Rundown: Contrast used in angiography is...
1. The study demonstrated that acute kidney injury (AKI) is common in critically ill children and young adults, and is associated with increased mortality. 2. The majority of patients meeting the definition of AKI were missed when only the plasma creatinine criteria was used to make a diagnosis. Evidence Rating: 2...
1. Fenoldopam did not significantly improve mortality or reduce dialysis initiation in patients with acute kidney injury (AKI) after cardiac surgery. 2. The patients receiving fenoldopam had significantly higher rates of hypotension than the control group. Evidence Rating Level: 1 (Excellent) Study Rundown: Acute kidney injury (AKI) is a common post-operative complication after cardiac...
1. In a large patient cohort, the use intravenous iodinated contrast was not associated with a significantly increased risk of acute kidney injury (AKI), dialysis, or mortality, even among patients with significant renal risk factors. 2. The incidence of AKI following CT imaging was 5% and increased as a...
1.   Atypical antipsychotics given to elderly patients in outpatient setting were associated with a 75% increased 90-day risk of hospitalization for acute kidney injury (AKI) when compared to untreated controls. 2.  Older patients taking atypical antipsychotics were nearly twice as likely to develop multiple severe complications, including death.  Evidence Rating Level:...
Image: PD In this section, we highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Effectiveness of Paliperidone Palmitate vs Haloperidol Decanoate for Maintenance Treatment of Schizophrenia Recent studies have showed older antipsychotic medications to be noninferior in safety and efficacy to newer atypical antipsychotics; older...